8I1O
 
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7S5S
 | | CTX-M-15 WT in complex with BLIP WT | | 分子名称: | Beta-lactamase, Beta-lactamase inhibitory protein | | 著者 | Lu, S, Palzkill, T, Hu, L.Y, Prasad, B.V.V, Sankaran, B. | | 登録日 | 2021-09-11 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M beta-lactamase drug-resistance enzymes.
Nat Commun, 13, 2022
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8X1N
 | | Cryo-EM structure of human alpha-fetoprotein | | 分子名称: | Alpha-fetoprotein, PALMITIC ACID, ZINC ION, ... | | 著者 | Liu, Z.M, Li, M.S, Wu, C, Liu, K. | | 登録日 | 2023-11-08 | | 公開日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Structural characteristics of alpha-fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites.
Commun Biol, 7, 2024
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8I1M
 | | Crystal structure of oxidated APSK1 domain from human PAPSS1 in complex with APS and ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-PHOSPHOSULFATE, PAPSS1 protein, ... | | 著者 | Zhang, L, Song, W.Y, Zhang, L. | | 登録日 | 2023-01-13 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-07-19 | | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | | 主引用文献 | Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2.
Structure, 31, 2023
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3N9L
 | | ceKDM7A from C.elegans, complex with H3K4me3 peptide and NOG | | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | | 登録日 | 2010-05-31 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
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3N9M
 | | ceKDM7A from C.elegans, alone | | 分子名称: | FE (II) ION, Putative uncharacterized protein, ZINC ION | | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | | 登録日 | 2010-05-31 | | 公開日 | 2010-06-30 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.493 Å) | | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
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7BTN
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3N9Q
 | | ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K27me2 peptide and NOG | | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | | 登録日 | 2010-05-31 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
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3N9N
 | | ceKDM7A from C.elegans, complex with H3K4me3K9me2 peptide and NOG | | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | | 登録日 | 2010-05-31 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
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3N9P
 | | ceKDM7A from C.elegans, complex with H3K4me3K27me2 peptide and NOG | | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | | 登録日 | 2010-05-31 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.388 Å) | | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
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3N9O
 | | ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K9me2 peptide and NOG | | 分子名称: | FE (II) ION, Histone H3 peptide, N-OXALYLGLYCINE, ... | | 著者 | Yang, Y, Hu, L, Wang, P, Hou, H, Chen, C.D, Xu, Y. | | 登録日 | 2010-05-31 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.309 Å) | | 主引用文献 | Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
Cell Res., 20, 2010
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4X3O
 | | Sirt2 in complex with a myristoyl peptide | | 分子名称: | 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... | | 著者 | Wang, Y, Zhang, W.Z, Hao, Q. | | 登録日 | 2014-12-01 | | 公開日 | 2016-01-13 | | 最終更新日 | 2022-04-20 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure.
Cell Chem Biol, 24, 2017
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4X3P
 | | Sirt2 in complex with a myristoyl peptide | | 分子名称: | 1,2-ETHANEDIOL, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NAD-dependent protein deacetylase sirtuin-2, ... | | 著者 | Wang, Y, Zhang, W, Hao, Q. | | 登録日 | 2014-12-01 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure.
Cell Chem Biol, 24, 2017
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7LEX
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7LEZ
 | | Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex | | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb1 heavy chain, ... | | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | | 登録日 | 2021-01-15 | | 公開日 | 2021-09-01 | | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
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7LF1
 | | Trimeric human Arginase 1 in complex with mAb3 | | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb3 heavy chain, ... | | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | | 登録日 | 2021-01-15 | | 公開日 | 2021-09-01 | | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
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7LEY
 | | Trimeric human Arginase 1 in complex with mAb5 | | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb5 heavy chain, ... | | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | | 登録日 | 2021-01-15 | | 公開日 | 2021-09-01 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
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7LF0
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7LF2
 | | Trimeric human Arginase 1 in complex with mAb4 | | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb4 monoclonal antibody heavy chain, ... | | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | | 登録日 | 2021-01-15 | | 公開日 | 2021-09-01 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.
Commun Biol, 4, 2021
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2RPN
 | | A crucial role for high intrinsic specificity in the function of yeast SH3 domains | | 分子名称: | Actin-binding protein, Actin-regulating kinase 1 | | 著者 | Stollar, E.J, Garcia, B, Chong, A, Forman-Kay, J, Davidson, A. | | 登録日 | 2008-06-12 | | 公開日 | 2009-06-16 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p
J.Biol.Chem., 284, 2009
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8F86
 | | SIRT6 bound to an H3K9Ac nucleosome | | 分子名称: | DNA (148-MER), Histone H2A type 1, Histone H2B, ... | | 著者 | Markert, J, Whedon, S, Wang, Z, Cole, P, Farnung, L. | | 登録日 | 2022-11-21 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation.
J.Am.Chem.Soc., 145, 2023
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9AZX
 | | Crystal structure of SARS-CoV-2 (Covid-19) Nsp3 macrodomain in complex with NDPr | | 分子名称: | Non-structural protein 3, {(2R,3S,4R,5R)-5-[(8S)-4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl]-5-cyano-3,4-dihydroxyoxolan-2-yl}methyl [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate | | 著者 | Wallace, S.D, Bagde, S.R, Fromme, J.C. | | 登録日 | 2024-03-11 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.395 Å) | | 主引用文献 | GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains.
Acs Chem.Biol., 19, 2024
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8JMZ
 | | FGFR1 kinase domain with sulfatinib | | 分子名称: | Fibroblast growth factor receptor 1, GLYCEROL, N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide, ... | | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | | 登録日 | 2023-06-05 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.988 Å) | | 主引用文献 | Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
Commun Chem, 7, 2024
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4R8M
 | | Human SIRT2 crystal structure in complex with BHJH-TM1 | | 分子名称: | BHJH-TM1 peptide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... | | 著者 | Teng, Y.B, Hao, Q, Lin, H.N, Jing, H. | | 登録日 | 2014-09-02 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies
Sci Rep, 5, 2015
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8JOT
 | | Crystal structure of CSF-1R kinase domain with sulfatinib | | 分子名称: | GLYCEROL, Macrophage colony-stimulating factor 1 receptor, N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide | | 著者 | Lin, Q.M, Chen, X.J, Chen, Y.H. | | 登録日 | 2023-06-08 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
Commun Chem, 7, 2024
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