9AZX

Crystal structure of SARS-CoV-2 (Covid-19) Nsp3 macrodomain in complex with NDPr

This is a non-PDB format compatible entry.

Summary for 9AZX

• Entry DOI: 10.2210/pdb9azx/pdb
• Descriptor: Non-structural protein 3, {(2R,3S,4R,5R)-5-[(8S)-4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl]-5-cyano-3,4-dihydroxyoxolan-2-yl}methyl [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl dihydrogen diphosphate (3 entities in total)
• Functional Keywords: viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 3
• Total formula weight: 56577.32

Authors

Wallace, S.D.,Bagde, S.R.,Fromme, J.C. (deposition date: 2024-03-11, release date: 2024-05-01)

• Primary citation: Peng, K.,Wallace, S.D.,Bagde, S.R.,Shang, J.,Anmangandla, A.,Jana, S.,Fromme, J.C.,Lin, H.; GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains.; Acs Chem.Biol., 2024; PubMed: 38646883; DOI: 10.1021/acschembio.4c00027

Experimental method

X-RAY DIFFRACTION (1.395 Å)