3V45
 
 | | Crystal Structure of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium Target OR130 | | 分子名称: | CHLORIDE ION, SODIUM ION, Serine hydrolase OSH55 | | 著者 | Kuzin, A, Su, M, Seetharaman, J, Maglaqui, M, Xiao, R, Kohan, E, Rajagopalan, S, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2011-12-14 | | 公開日 | 2012-01-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
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2RHB
 | | Crystal structure of Nsp15-H234A mutant- Hexamer in asymmetric unit | | 分子名称: | Uridylate-specific endoribonuclease | | 著者 | Palaninathan, S, Bhardwaj, K, Alcantara, J.M.O, Guarino, L, Yi, L.L, Kao, C.C, Sacchettini, J. | | 登録日 | 2007-10-08 | | 公開日 | 2007-11-27 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15.
J.Biol.Chem., 283, 2008
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5WKZ
 | | VH1-69 germline antibody predicted from CR6261 | | 分子名称: | Immunoglobulin heavy variable 1-69D,IgG H chain, Lambda-chain (AA -20 to 215), SULFATE ION | | 著者 | Lang, S, Lee, P.S. | | 登録日 | 2017-07-25 | | 公開日 | 2018-08-01 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Anti-idiotypic antibody K1-18 engages VH1-69 precursor and affinity-matured, anti-stem antibodies through mimicry of the HA stem
To Be Published
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6F1F
 | | The methylene thioacetal BPTI (Bovine Pancreatic Trypsin Inhibitor) mutant structure | | 分子名称: | GLYCEROL, Pancreatic trypsin inhibitor, SULFATE ION | | 著者 | Lansky, S, Mousa, R, Metanis, N, Shoham, G. | | 登録日 | 2017-11-21 | | 公開日 | 2018-07-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.716 Å) | | 主引用文献 | BPTI folding revisited: switching a disulfide into methylene thioacetal reveals a previously hidden path.
Chem Sci, 9, 2018
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5WKO
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3T03
 | | Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16 | | 分子名称: | (5Z)-5-(5-bromo-2-methoxybenzylidene)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma | | 著者 | Rajagopalan, S, Webb, P, Baxter, J.D, Brennan, R.G, Phillips, K.J. | | 登録日 | 2011-07-19 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | GQ-16, a novel peroxisome proliferator-activated receptor (PPAR gamma) ligand, promotes insulin sensitization without weight gain.
J.Biol.Chem., 287, 2012
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4DRT
 | | Three dimensional structure of de novo designed serine hydrolase OSH26, Northeast Structural Genomics Consortium (NESG) target OR89 | | 分子名称: | CHLORIDE ION, SODIUM ION, de novo designed serine hydrolase, ... | | 著者 | Kuzin, A, Su, M, Rajagopalan, S, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-02-17 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
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4EUO
 | | Structure of Atu4243-GABA sensor | | 分子名称: | ABC transporter, substrate binding protein (Polyamine), GAMMA-AMINO-BUTANOIC ACID, ... | | 著者 | Morera, S, Planamente, S. | | 登録日 | 2012-04-25 | | 公開日 | 2012-11-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Structural basis for selective GABA binding in bacterial pathogens.
Mol.Microbiol., 86, 2012
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4F2V
 | | Crystal Structure of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR165 | | 分子名称: | DI(HYDROXYETHYL)ETHER, DODECYL-ALPHA-D-MALTOSIDE, De novo designed serine hydrolase | | 著者 | Kuzin, A, Lew, S, Seetharaman, J, Maglaqui, M, Xiao, R, Kohan, E, Rajagopalan, S, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-05-08 | | 公開日 | 2012-05-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.493 Å) | | 主引用文献 | Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
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4EQ7
 | | Structure of Atu4243-GABA receptor | | 分子名称: | ABC transporter, substrate binding protein (Polyamine), GLYCEROL, ... | | 著者 | Morera, S, Planamente, S. | | 登録日 | 2012-04-18 | | 公開日 | 2012-11-21 | | 最終更新日 | 2012-12-19 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Structural basis for selective GABA binding in bacterial pathogens.
Mol.Microbiol., 86, 2012
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4ETK
 | | Crystal Structure of E6A/L130D/A155H variant of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR186 | | 分子名称: | De novo designed serine hydrolase, SODIUM ION | | 著者 | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-04-24 | | 公開日 | 2012-06-13 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
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4ETJ
 | | Crystal Structure of E6H variant of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium (NESG) Target OR185 | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CHLORIDE ION, ... | | 著者 | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-04-24 | | 公開日 | 2012-06-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | | 主引用文献 | Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
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4ESS
 | | Crystal Structure of E6D/L155R variant of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium (NESG) Target OR187 | | 分子名称: | OR187 | | 著者 | Kuzin, A, Su, M, Seetharaman, J, Kornhaber, K, Kornhaber, G, Rajagopalan, S, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2012-04-23 | | 公開日 | 2012-06-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9971 Å) | | 主引用文献 | Design of activated serine-containing catalytic triads with atomic-level accuracy.
Nat.Chem.Biol., 10, 2014
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6H3M
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5AER
 | | Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with D2 dopamine receptor peptide from Homo sapiens | | 分子名称: | CALCIUM ION, D(2) DOPAMINE RECEPTOR, NEURONAL CALCIUM SENSOR 1, ... | | 著者 | Saleem, M, Karuppiah, V, Pandalaneni, S, Burgoyne, R, Derrick, J.P, Lian, L.Y. | | 登録日 | 2015-01-08 | | 公開日 | 2015-02-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein-Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions.
J.Biol.Chem., 290, 2015
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5AEQ
 | | Neuronal calcium sensor (NCS-1)from Rattus norvegicus | | 分子名称: | CALCIUM ION, NEURONAL CALCIUM SENSOR 1, SODIUM ION | | 著者 | Saleem, M, Karuppiah, V, Pandalaneni, S, Burgoyne, R, Derrick, J.P, Lian, L.Y. | | 登録日 | 2015-01-08 | | 公開日 | 2015-02-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein-Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions.
J.Biol.Chem., 290, 2015
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5AFP
 | | Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with rhodopsin kinase peptide from Homo sapiens | | 分子名称: | CALCIUM ION, NEURONAL CALCIUM SENSOR 1, RHODOPSIN KINASE, ... | | 著者 | Saleem, M, Karuppiah, V, Pandalaneni, S, Burgoyne, R, Derrick, J.P, Lian, L.Y. | | 登録日 | 2015-01-23 | | 公開日 | 2015-03-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions.
J.Biol.Chem., 290, 2015
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4E9D
 | | The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide | | 分子名称: | 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide, GLYCEROL, Serine/threonine-protein kinase PLK1 | | 著者 | Sledz, P, Hyvonen, M, Lang, S, Stubbs, C.J, Abell, C. | | 登録日 | 2012-03-21 | | 公開日 | 2012-10-10 | | 最終更新日 | 2012-12-12 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | High-throughput interrogation of ligand binding mode using a fluorescence-based assay.
Angew.Chem.Int.Ed.Engl., 51, 2012
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4D0R
 | | Mtb InhA complex with Pyradizinone compound 1 | | 分子名称: | 4-(4-chlorophenoxy)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Read, J.A, Gingell, H, Madhavapeddi, P, Lange, S. | | 登録日 | 2014-04-29 | | 公開日 | 2015-05-20 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Pyridazinones: A Novel Scaffold with Excellent Physicochemical Properties and Safety Profile for a Clinically Validated Target of Mycobacterium Tuberculosis
To be Published
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4D0S
 | | Mtb InhA complex with Pyradizinone compound 14 | | 分子名称: | 1-{4-[(acetylamino)methyl]phenyl}-4-(4-chlorophenoxy)-6-oxo-1,6-dihydropyridazine-3-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], MAGNESIUM ION, ... | | 著者 | Read, J.A, Breed, J, Madhavapeddi, P, Lange, S. | | 登録日 | 2014-04-29 | | 公開日 | 2015-05-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Pyridazinones: A Novel Scaffold with Excellent Physicochemical Properties and Safety Profile for a Clinically Validated Target of Mycobacterium Tuberculosis
To be Published
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4UQZ
 | | Coevolution of the ATPase ClpV, the TssB-TssC Sheath and the Accessory HsiE Protein Distinguishes Two Type VI Secretion Classes | | 分子名称: | ACETATE ION, HSIB1, HSIE1 | | 著者 | Forster, A, Planamente, S, Manoli, E, Lossi, N.S, Freemont, P.S, Filloux, A. | | 登録日 | 2014-06-25 | | 公開日 | 2014-10-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | | 主引用文献 | Coevolution of the ATPase Clpv, the Sheath Proteins Tssb and Tssc and the Accessory Protein Tagj/Hsie1 Distinguishes Type Vi Secretion Classes.
RNA, 20, 2014
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1K1G
 | | STRUCTURAL BASIS FOR RECOGNITION OF THE INTRON BRANCH SITE RNA BY SPLICING FACTOR 1 | | 分子名称: | 5'-R(*UP*AP*UP*AP*CP*UP*AP*AP*CP*AP*A)-3', SF1-Bo isoform | | 著者 | Liu, Z, Luyten, I, Bottomley, M.J, Messias, A.C, Houngninou-Molango, S, Sprangers, R, Zanier, K, Kramer, A, Sattler, M. | | 登録日 | 2001-09-25 | | 公開日 | 2001-11-07 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for recognition of the intron branch site RNA by splicing factor 1.
Science, 294, 2001
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3MWP
 | | Nucleoprotein structure of lassa fever virus | | 分子名称: | Nucleoprotein, ZINC ION | | 著者 | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | | 登録日 | 2010-05-06 | | 公開日 | 2010-12-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | | 主引用文献 | Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
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3MX5
 | | Lassa fever virus nucleoprotein complexed with UTP | | 分子名称: | Nucleoprotein, URIDINE 5'-TRIPHOSPHATE, ZINC ION | | 著者 | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | | 登録日 | 2010-05-06 | | 公開日 | 2010-12-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | | 主引用文献 | Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
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3MWT
 | | Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+ | | 分子名称: | MANGANESE (II) ION, Nucleoprotein, ZINC ION | | 著者 | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | | 登録日 | 2010-05-06 | | 公開日 | 2010-12-01 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.982 Å) | | 主引用文献 | Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
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