4ETK

Crystal Structure of E6A/L130D/A155H variant of de novo designed serine hydrolase, Northeast Structural Genomics Consortium (NESG) Target OR186

Summary for 4ETK

• Entry DOI: 10.2210/pdb4etk/pdb
• Related: 3V45
• Descriptor: De novo designed serine hydrolase, SODIUM ION (3 entities in total)
• Functional Keywords: structural genomics, psi-biology, protein structure initiative, northeast structural genomics consortium, nesg, hydrolase
• Biological source: artificial gene
• Total number of polymer chains: 2
• Total formula weight: 35582.98

Authors

Kuzin, A.,Su, M.,Seetharaman, J.,Kornhaber, K.,Kornhaber, G.,Rajagopalan, S.,Baker, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2012-04-24, release date: 2012-06-13, Last modification date: 2023-12-06)

• Primary citation: Rajagopalan, S.,Wang, C.,Yu, K.,Kuzin, A.P.,Richter, F.,Lew, S.,Miklos, A.E.,Matthews, M.L.,Seetharaman, J.,Su, M.,Hunt, J.F.,Cravatt, B.F.,Baker, D.; Design of activated serine-containing catalytic triads with atomic-level accuracy.; Nat.Chem.Biol., 10:386-391, 2014; PubMed: 24705591; DOI: 10.1038/nchembio.1498

Experimental method

X-RAY DIFFRACTION (2.7 Å)