4D0S

Mtb InhA complex with Pyradizinone compound 14

Summary for 4D0S

• Entry DOI: 10.2210/pdb4d0s/pdb
• Related: 4D0R
• Descriptor: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-{4-[(acetylamino)methyl]phenyl}-4-(4-chlorophenoxy)-6-oxo-1,6-dihydropyridazine-3-carboxamide, ... (5 entities in total)
• Functional Keywords: oxidoreductase, inha, acp enoyl reductase, methyl-thiazole
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 4
• Total formula weight: 118572.74

Authors

Read, J.A.,Breed, J.,Madhavapeddi, P.,Lange, S. (deposition date: 2014-04-29, release date: 2015-05-20, Last modification date: 2023-12-20)

• Primary citation: Lange, S.; Pyridazinones: A Novel Scaffold with Excellent Physicochemical Properties and Safety Profile for a Clinically Validated Target of Mycobacterium Tuberculosis; To be Published,

Experimental method

X-RAY DIFFRACTION (1.64 Å)