4ETJ

Crystal Structure of E6H variant of de novo designed serine hydrolase OSH55, Northeast Structural Genomics Consortium (NESG) Target OR185

Summary for 4ETJ

• Entry DOI: 10.2210/pdb4etj/pdb
• Related: 3V45
• Descriptor: Serine hydrolase, CHLORIDE ION, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (6 entities in total)
• Functional Keywords: structural genomics, psi-biology, protein structure initiative, northeast structural genomics consortium, nesg, de novo protein
• Biological source: artificial gene
• Total number of polymer chains: 1
• Total formula weight: 18834.97

Authors

Kuzin, A.,Su, M.,Seetharaman, J.,Kornhaber, K.,Kornhaber, G.,Rajagopalan, S.,Baker, D.,Everett, J.K.,Acton, T.B.,Montelione, G.T.,Tong, L.,Hunt, J.F.,Northeast Structural Genomics Consortium (NESG) (deposition date: 2012-04-24, release date: 2012-06-13, Last modification date: 2023-09-13)

• Primary citation: Rajagopalan, S.,Wang, C.,Yu, K.,Kuzin, A.P.,Richter, F.,Lew, S.,Miklos, A.E.,Matthews, M.L.,Seetharaman, J.,Su, M.,Hunt, J.F.,Cravatt, B.F.,Baker, D.; Design of activated serine-containing catalytic triads with atomic-level accuracy.; Nat.Chem.Biol., 10:386-391, 2014; PubMed: 24705591; DOI: 10.1038/nchembio.1498

Experimental method

X-RAY DIFFRACTION (2.203 Å)