4E9D

The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide

Summary for 4E9D

Entry DOI	10.2210/pdb4e9d/pdb
Related	4E67 4E9C
Related PRD ID	PRD_000810
Descriptor	Serine/threonine-protein kinase PLK1, 3-(1-benzothiophen-2-yl)propanoyl-derivatized DPPLHSpTA peptide, GLYCEROL, ... (4 entities in total)
Functional Keywords	serine/threonine kinase, transferase, phosphoprotein binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P53350
Total number of polymer chains	2
Total formula weight	27951.74
Authors	Sledz, P.,Hyvonen, M.,Lang, S.,Stubbs, C.J.,Abell, C. (deposition date: 2012-03-21, release date: 2012-10-10, Last modification date: 2024-10-16)
Primary citation	Lang, S.,Stubbs, C.J.,Abell, C. High-throughput interrogation of ligand binding mode using a fluorescence-based assay. Angew.Chem.Int.Ed.Engl., 51:7680-7683, 2012 Cited by PubMed Abstract: Probing the pocket: A high-throughput fluorescence-based thermal shift (FTS) assay utilized different forms of a protein (in gray) to establish the binding mode of a ligand (see picture). The assay serves in the rapid evaluation of structure-activity binding-mode relationships for a series of ligands of Plk1, an important target of anticancer therapy. PubMed: 22730171 DOI: 10.1002/anie.201202660 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.75 Å)

Structure validation