4E67
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide
Summary for 4E67
Entry DOI | 10.2210/pdb4e67/pdb |
Related | 4E9C 4E9D |
Related PRD ID | PRD_000807 |
Descriptor | Serine/threonine-protein kinase PLK1, hydrocinnamoyl-derivatized PLHSpTA peptide (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, transferase, phosphoprotein-binding domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P53350 |
Total number of polymer chains | 2 |
Total formula weight | 27591.36 |
Authors | Sledz, P.,Hyvonen, M.,Tan, Y.S.,Lang, S.,Spring, D.,Abell, C.,Best, R.B. (deposition date: 2012-03-15, release date: 2012-10-10, Last modification date: 2023-09-13) |
Primary citation | Tan, Y.S.,Sledz, P.,Lang, S.,Stubbs, C.J.,Spring, D.R.,Abell, C.,Best, R.B. Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1. Angew.Chem.Int.Ed.Engl., 51:10078-10081, 2012 Cited by PubMed: 22961729DOI: 10.1002/anie.201205676 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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