8IM3
 
 | | Crystal structure of human HPPD complexed with compound a10 | | 分子名称: | 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION, [1,3-diethyl-2,2-bis(oxidanylidene)-2$l^{6},1,3-benzothiadiazol-5-yl]-(1-methyl-5-oxidanyl-pyrazol-4-yl)methanone | | 著者 | Dong, J, Lin, H.-Y. | | 登録日 | 2023-03-05 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.
Structure, 31, 2023
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8IM2
 | | Crystal structure of human HPPD complexed with NTBC | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE, 4-hydroxyphenylpyruvate dioxygenase, ... | | 著者 | Dong, J, Lin, H.-Y, Yang, G.-F. | | 登録日 | 2023-03-05 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors.
Structure, 31, 2023
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6DLB
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6DLA
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6DL8
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5H85
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5HCL
 | | Crystal Structure of the first bromodomain of BRD4 in complex with DMA | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N},~{N}-dimethylethanamide | | 著者 | Dong, J, Weber, F.E, Caflisch, A. | | 登録日 | 2016-01-04 | | 公開日 | 2017-01-25 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment.
Sci Rep, 7, 2017
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6P9J
 | | crystal structure of human anti staphylococcus aureus antibody STAU-229 Fab | | 分子名称: | TRIS(HYDROXYETHYL)AMINOMETHANE, human anti staphylococcus aureus antibody STAU-229 Fab heavy chain, human anti staphylococcus aureus antibody STAU-229 Fab light chain | | 著者 | Dong, J, Crowe, J.E. | | 登録日 | 2019-06-10 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis.
Mbio, 10, 2019
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6P9I
 | | crystal structure of human anti staphylococcus aureus antibody STAU-399 Fab | | 分子名称: | human anti staphylococcus aureus antibody STAU-399 Fab heavy chain, human anti staphylococcus aureus antibody STAU-399 Fab light chain | | 著者 | Dong, J, Crowe, J.E. | | 登録日 | 2019-06-10 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Human V H 1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis.
Mbio, 10, 2019
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6P9H
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5JRP
 | | crystal structure of monoclonal antibody MR78 Fab | | 分子名称: | SODIUM ION, marberg virus monoclonal antibody MR78 Fab heavy chain, marberg virus monoclonal antibody MR78 Fab light chain | | 著者 | Dong, J, Crowe, J. | | 登録日 | 2016-05-06 | | 公開日 | 2017-11-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
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4GF6
 | | crystal structure of GFP with cuprum bound at the Incorporated metal Chelating Amino Acid PYZ151 | | 分子名称: | CALCIUM ION, COPPER (II) ION, green fluorescent protein | | 著者 | Dong, J, Liu, X, Li, J, Wang, J, Gong, W. | | 登録日 | 2012-08-03 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Genetic incorporation of a metal-chelating amino Acid as a probe for protein electron transfer.
Angew.Chem.Int.Ed.Engl., 51, 2012
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4GES
 | | crystal structure of GFP-TYR151PYZ with an unnatural amino acid incorporation | | 分子名称: | Green fluorescent protein | | 著者 | Dong, J, Liu, X, Li, J, Wang, J, Gong, W. | | 登録日 | 2012-08-02 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Genetic incorporation of a metal-chelating amino Acid as a probe for protein electron transfer.
Angew.Chem.Int.Ed.Engl., 51, 2012
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3K3Q
 | | Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain | | 分子名称: | Botulinum neurotoxin type A, ZINC ION, llama Aa1 VHH domain | | 著者 | Thompson, A.A, Dong, J, Marks, J.D, Stevens, R.C. | | 登録日 | 2009-10-04 | | 公開日 | 2010-02-23 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region.
J.Mol.Biol., 397, 2010
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3K8A
 | | Neisseria gonorrhoeae PriB | | 分子名称: | Putative primosomal replication protein | | 著者 | Lopper, M.E, Dong, J, George, N.P, Duckett, K.L, DeBeer, M.A. | | 登録日 | 2009-10-14 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The crystal structure of Neisseria gonorrhoeae PriB reveals mechanistic differences among bacterial DNA replication restart pathways
Nucleic Acids Res., 38, 2010
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4G2F
 | | Human EphA3 kinase domain in complex with compound 7 | | 分子名称: | 1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5H)-one, EPH receptor A3 | | 著者 | Dong, J, Caflisch, A. | | 登録日 | 2012-07-12 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | | 主引用文献 | Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.
ACS MED.CHEM.LETT., 3, 2012
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4GK3
 | | Human EphA3 Kinase domain in complex with ligand 87 | | 分子名称: | 8-butyl-1-methyl-7-(2-methylphenyl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, EPH receptor A3 | | 著者 | Dong, J, Caflisch, A. | | 登録日 | 2012-08-10 | | 公開日 | 2013-01-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | | 主引用文献 | Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography.
J.Med.Chem., 56, 2013
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4GK2
 | | Human EphA3 Kinase domain in complex with ligand 66 | | 分子名称: | 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, EPH receptor A3 | | 著者 | Dong, J, Caflisch, A. | | 登録日 | 2012-08-10 | | 公開日 | 2013-01-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.195 Å) | | 主引用文献 | Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography.
J.Med.Chem., 56, 2013
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4GK4
 | | Human EphA3 Kinase domain in complex with ligand 90 | | 分子名称: | 8-butyl-1-methyl-7-(5-methyl-1H-indazol-4-yl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, EPH receptor A3 | | 著者 | Dong, J, Caflisch, A. | | 登録日 | 2012-08-10 | | 公開日 | 2013-01-23 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography.
J.Med.Chem., 56, 2013
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4TQN
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4RVZ
 | | Crystal structure of tRNA fluorescent labeling enzyme | | 分子名称: | MAGNESIUM ION, N-(4-aminobutyl)-2-azidoacetamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Dong, J, Li, F, Wang, J, Gong, W. | | 登録日 | 2014-11-29 | | 公開日 | 2015-03-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A covalent approach for site-specific RNA labeling in Mammalian cells.
Angew.Chem.Int.Ed.Engl., 54, 2015
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8HOW
 | | Crystal structure of AtHPPD-Y191052 complex | | 分子名称: | 1,5-dimethyl-6-(2-oxidanyl-6-oxidanylidene-cyclohexen-1-yl)carbonyl-3-(2-phenylethyl)quinazoline-2,4-dione, 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION | | 著者 | Yang, G.-F, Lin, H.-Y, Dong, J. | | 登録日 | 2022-12-11 | | 公開日 | 2023-01-25 | | 最終更新日 | 2023-02-01 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Discovery of Subnanomolar Inhibitors of 4-Hydroxyphenylpyruvate Dioxygenase via Structure-Based Rational Design.
J.Agric.Food Chem., 71, 2023
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4P4C
 | | Human EphA3 Kinase domain in complex with quinoxaline derivatives | | 分子名称: | 2-amino-1-(3-methoxyphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, EPH receptor A3 | | 著者 | Dong, J, Caflisch, A. | | 登録日 | 2014-03-12 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | | 主引用文献 | Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation.
J.Med.Chem., 57, 2014
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4PCE
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with compound B13 | | 分子名称: | 1,2-ETHANEDIOL, 1-benzyl-2-ethyl-1,5,6,7-tetrahydro-4H-indol-4-one, Bromodomain-containing protein 4 | | 著者 | Dong, J, Caflisch, A. | | 登録日 | 2014-04-15 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.293 Å) | | 主引用文献 | Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking.
Bioorg.Med.Chem.Lett., 24, 2014
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4Q2V
 | | Crystal Structure of Ricin A chain complexed with Baicalin inhibitor | | 分子名称: | 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid, Ricin | | 著者 | Deng, X, Li, X, Dong, J, Chen, Y. | | 登録日 | 2014-04-10 | | 公開日 | 2015-04-15 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | | 主引用文献 | Baicalin inhibits the lethality of ricin in mice by inducing protein oligomerization.
J.Biol.Chem., 290, 2015
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