3K3Q
Crystal Structure of a Llama Antibody complexed with the C. Botulinum Neurotoxin Serotype A Catalytic Domain
Summary for 3K3Q
| Entry DOI | 10.2210/pdb3k3q/pdb |
| Descriptor | llama Aa1 VHH domain, Botulinum neurotoxin type A, ZINC ION, ... (5 entities in total) |
| Functional Keywords | llama, vhh, antibody, botulinum, neurotoxin, bont, cell junction, cell membrane, cytoplasm, disulfide bond, hydrolase, membrane, metal-binding, metalloprotease, pharmaceutical, protease, secreted, synapse, toxin, transmembrane, zinc, immune system |
| Biological source | Lama glama More |
| Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9 A5HZZ9 |
| Total number of polymer chains | 3 |
| Total formula weight | 65194.77 |
| Authors | Thompson, A.A.,Dong, J.,Marks, J.D.,Stevens, R.C. (deposition date: 2009-10-04, release date: 2010-02-23, Last modification date: 2017-11-01) |
| Primary citation | Dong, J.,Thompson, A.A.,Fan, Y.,Lou, J.,Conrad, F.,Ho, M.,Pires-Alves, M.,Wilson, B.A.,Stevens, R.C.,Marks, J.D. A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region. J.Mol.Biol., 397:1106-1118, 2010 Cited by PubMed: 20138889DOI: 10.1016/j.jmb.2010.01.070 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report
