4G2F

Human EphA3 kinase domain in complex with compound 7

Summary for 4G2F

Entry DOI	10.2210/pdb4g2f/pdb
Descriptor	EPH receptor A3, 1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5H)-one (3 entities in total)
Functional Keywords	receptor tyrosine kinase, atp binding, phosphorylation, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40780.54
Authors	Dong, J.,Caflisch, A. (deposition date: 2012-07-12, release date: 2012-10-24, Last modification date: 2023-11-08)
Primary citation	Zhao, H.,Dong, J.,Lafleur, K.,Nevado, C.,Caflisch, A. Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics. ACS MED.CHEM.LETT., 3:834-838, 2012 Cited by PubMed: 24900387 DOI: 10.1021/ml3001984 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.699 Å)

Structure validation