4G2F
Human EphA3 kinase domain in complex with compound 7
Summary for 4G2F
Entry DOI | 10.2210/pdb4g2f/pdb |
Descriptor | EPH receptor A3, 1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5H)-one (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, atp binding, phosphorylation, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40780.54 |
Authors | Dong, J.,Caflisch, A. (deposition date: 2012-07-12, release date: 2012-10-24, Last modification date: 2023-11-08) |
Primary citation | Zhao, H.,Dong, J.,Lafleur, K.,Nevado, C.,Caflisch, A. Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics. ACS MED.CHEM.LETT., 3:834-838, 2012 Cited by PubMed: 24900387DOI: 10.1021/ml3001984 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.699 Å) |
Structure validation
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