4G2F

Human EphA3 kinase domain in complex with compound 7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	EPH receptor A3	polymer	361	40458.2	1	UniProt (Q6P4R6) Pfam (PF07714) Pfam (PF07647) UniProt (by SIFTS) (P29320)	Homo sapiens (human)
2	B (A)	1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5H)-one	non-polymer		322.4	1	Chemie (C07)
3	C (A)	water	water		18.0	225	Chemie (HOH)

Sequence modifications

A: 606 - 947 (UniProt: Q6P4R6)

PDB	External Database	Details
Met 587	-	expression tag
Gly 588	-	expression tag
Ser 589	-	expression tag
Ser 590	-	expression tag
His 591	-	expression tag
His 592	-	expression tag
His 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
Ser 597	-	expression tag
Ser 598	-	expression tag
Gly 599	-	expression tag
Leu 600	-	expression tag
Val 601	-	expression tag
Pro 602	-	expression tag
Arg 603	-	expression tag
Gly 604	-	expression tag
Ser 605	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40458.2
Non-Polymers*	Number of molecules	1
	Total formula weight	322.4
All*	Total formula weight	40780.5

*Water molecules are not included.