8IM2
Crystal structure of human HPPD complexed with NTBC
Summary for 8IM2
Entry DOI | 10.2210/pdb8im2/pdb |
Descriptor | 4-hydroxyphenylpyruvate dioxygenase, COBALT (II) ION, 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE, ... (5 entities in total) |
Functional Keywords | enzyme, inhibitor, complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 273015.51 |
Authors | Dong, J.,Lin, H.-Y.,Yang, G.-F. (deposition date: 2023-03-05, release date: 2023-10-18, Last modification date: 2023-12-27) |
Primary citation | Dong, J.,Xiao, H.,Chen, J.N.,Zheng, B.F.,Xu, Y.L.,Chen, M.X.,Yang, W.C.,Lin, H.Y.,Yang, G.F. Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors. Structure, 31:1604-, 2023 Cited by PubMed: 37794595DOI: 10.1016/j.str.2023.09.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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