8IM2

Crystal structure of human HPPD complexed with NTBC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001734	molecular_function	mRNA m(6)A methyltransferase activity
A	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006559	biological_process	L-phenylalanine catabolic process
A	0006572	biological_process	L-tyrosine catabolic process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
A	0042803	molecular_function	protein homodimerization activity
A	0070062	cellular_component	extracellular exosome
B	0000139	cellular_component	Golgi membrane
B	0001734	molecular_function	mRNA m(6)A methyltransferase activity
B	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006559	biological_process	L-phenylalanine catabolic process
B	0006572	biological_process	L-tyrosine catabolic process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
B	0042803	molecular_function	protein homodimerization activity
B	0070062	cellular_component	extracellular exosome
C	0000139	cellular_component	Golgi membrane
C	0001734	molecular_function	mRNA m(6)A methyltransferase activity
C	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0006559	biological_process	L-phenylalanine catabolic process
C	0006572	biological_process	L-tyrosine catabolic process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
C	0042803	molecular_function	protein homodimerization activity
C	0070062	cellular_component	extracellular exosome
D	0000139	cellular_component	Golgi membrane
D	0001734	molecular_function	mRNA m(6)A methyltransferase activity
D	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0006559	biological_process	L-phenylalanine catabolic process
D	0006572	biological_process	L-tyrosine catabolic process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
D	0042803	molecular_function	protein homodimerization activity
D	0070062	cellular_component	extracellular exosome
E	0000139	cellular_component	Golgi membrane
E	0001734	molecular_function	mRNA m(6)A methyltransferase activity
E	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0006559	biological_process	L-phenylalanine catabolic process
E	0006572	biological_process	L-tyrosine catabolic process
E	0009072	biological_process	aromatic amino acid metabolic process
E	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
E	0042803	molecular_function	protein homodimerization activity
E	0070062	cellular_component	extracellular exosome
F	0000139	cellular_component	Golgi membrane
F	0001734	molecular_function	mRNA m(6)A methyltransferase activity
F	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005829	cellular_component	cytosol
F	0006559	biological_process	L-phenylalanine catabolic process
F	0006572	biological_process	L-tyrosine catabolic process
F	0009072	biological_process	aromatic amino acid metabolic process
F	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
F	0042803	molecular_function	protein homodimerization activity
F	0070062	cellular_component	extracellular exosome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	786
Details	Domain: {"description":"VOC 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01163","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	948
Details	Domain: {"description":"VOC 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01163","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P49429","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P49429","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---