4GK4

Human EphA3 Kinase domain in complex with ligand 90

Summary for 4GK4
Related4GK2 4GK3
DescriptorEPH receptor A3, 8-butyl-1-methyl-7-(5-methyl-1H-indazol-4-yl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione (3 entities in total)
Functional Keywordsreceptor tyrosine kinase, atp-binding, phosphorylation, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight40849.61
Authors
Dong, J.,Caflisch, A. (deposition date: 2012-08-10, release date: 2013-01-23, Last modification date: 2018-06-20)
Primary citationCaflisch, A.,Dong, J.,Huang, D.,Lafleur, K.,Nevado, C.
Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography.
J.Med.Chem., 56:84-96, 2013
PubMed: 23253074
DOI: 110.1021/jm301187e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation
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PDB entries from 2021-06-16