4GK2
Human EphA3 Kinase domain in complex with ligand 66
Summary for 4GK2
Entry DOI | 10.2210/pdb4gk2/pdb |
Related | 4GK3 4GK4 |
Descriptor | EPH receptor A3, 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, atp-binding, phosphorylation, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40875.60 |
Authors | Dong, J.,Caflisch, A. (deposition date: 2012-08-10, release date: 2013-01-23, Last modification date: 2023-11-08) |
Primary citation | Lafleur, K.,Dong, J.,Huang, D.,Caflisch, A.,Nevado, C. Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography. J.Med.Chem., 56:84-96, 2013 Cited by PubMed: 23253074DOI: 10.1021/jm301187e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.195 Å) |
Structure validation
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