5H85
Crystal structure of the bromodomain of human CREBBP in complex with UO37D
Summary for 5H85
Entry DOI | 10.2210/pdb5h85/pdb |
Descriptor | CREB-binding protein, methyl 3-(7~{H}-purin-6-ylcarbamoyl)benzoate (3 entities in total) |
Functional Keywords | transcription, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14520.62 |
Authors | Dong, J.,Caflisch, A. (deposition date: 2015-12-23, release date: 2017-01-11, Last modification date: 2024-01-10) |
Primary citation | Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.701 Å) |
Structure validation
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