5H85

Crystal structure of the bromodomain of human CREBBP in complex with UO37D

Summary for 5H85

Entry DOI	10.2210/pdb5h85/pdb
Descriptor	CREB-binding protein, methyl 3-(7~{H}-purin-6-ylcarbamoyl)benzoate (3 entities in total)
Functional Keywords	transcription, inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14520.62
Authors	Dong, J.,Caflisch, A. (deposition date: 2015-12-23, release date: 2017-01-11, Last modification date: 2024-01-10)
Primary citation	Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543 DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.701 Å)

Structure validation