8HOG
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![BU of 8hog by Molmil](/molmil-images/mine/8hog) | Crystal structure of Bcl-2 in complex with sonrotoclax | 分子名称: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | 登録日 | 2022-12-10 | 公開日 | 2024-01-17 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
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8HOH
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![BU of 8hoh by Molmil](/molmil-images/mine/8hoh) | Crystal structure of Bcl-2 G101V in complex with sonrotoclax | 分子名称: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | 登録日 | 2022-12-10 | 公開日 | 2024-01-17 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
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8HOI
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![BU of 8hoi by Molmil](/molmil-images/mine/8hoi) | Crystal structure of Bcl-2 D103Y in complex with sonrotoclax | 分子名称: | Apoptosis regulator Bcl-2, FORMIC ACID, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | 登録日 | 2022-12-10 | 公開日 | 2024-01-17 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
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4ZHW
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![BU of 4zhw by Molmil](/molmil-images/mine/4zhw) | |
4ZHY
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![BU of 4zhy by Molmil](/molmil-images/mine/4zhy) | Crystal structure of a bacterial signalling complex | 分子名称: | FORMIC ACID, SULFATE ION, YfiB, ... | 著者 | Li, S, Li, T, Wang, Y, Bartlam, M. | 登録日 | 2015-04-27 | 公開日 | 2016-04-27 | 実験手法 | X-RAY DIFFRACTION (1.969 Å) | 主引用文献 | Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 Sci Rep, 5, 2015
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4ZHV
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![BU of 4zhv by Molmil](/molmil-images/mine/4zhv) | Crystal structure of a bacterial signalling protein | 分子名称: | SULFATE ION, YfiB | 著者 | Li, S, Li, T, Wang, Y, Bartlam, M. | 登録日 | 2015-04-27 | 公開日 | 2016-04-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.585 Å) | 主引用文献 | Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 Sci Rep, 5, 2015
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4ZHU
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![BU of 4zhu by Molmil](/molmil-images/mine/4zhu) | Crystal structure of a bacterial repressor protein | 分子名称: | SULFATE ION, YfiR | 著者 | Li, S, Li, T, Wang, Y, Bartlam, M. | 登録日 | 2015-04-27 | 公開日 | 2016-04-27 | 実験手法 | X-RAY DIFFRACTION (2.3968 Å) | 主引用文献 | Structural insights into YfiR sequestering by YfiB in Pseudomonas aeruginosa PAO1 Sci Rep, 5, 2015
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7XQV
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![BU of 7xqv by Molmil](/molmil-images/mine/7xqv) | The complex of nanobody Rh57 binding to GTP-bound RhoA active form | 分子名称: | ALANINE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Zhang, Y.R, Liu, R, Ding, Y. | 登録日 | 2022-05-09 | 公開日 | 2022-07-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structural insights into the binding of nanobody Rh57 to active RhoA-GTP. Biochem.Biophys.Res.Commun., 616, 2022
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7Y43
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5YKR
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![BU of 5ykr by Molmil](/molmil-images/mine/5ykr) | |
5YKT
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8DVH
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![BU of 8dvh by Molmil](/molmil-images/mine/8dvh) | Crystal structure of ATP-dependent Lon protease from Bacillus subtillis (BsLonBA) | 分子名称: | Lon protease 2, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, SODIUM ION | 著者 | Sekula, B, Li, M, Gustchina, A, Wlodawer, A. | 登録日 | 2022-07-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases. Int J Mol Sci, 23, 2022
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8QN7
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![BU of 8qn7 by Molmil](/molmil-images/mine/8qn7) | Amyloid-beta 40 type 1 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy | 分子名称: | Amyloid-beta A4 protein | 著者 | Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. | 登録日 | 2023-09-25 | 公開日 | 2023-12-13 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11, 2023
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8QN6
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![BU of 8qn6 by Molmil](/molmil-images/mine/8qn6) | Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy | 分子名称: | Amyloid-beta A4 protein | 著者 | Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. | 登録日 | 2023-09-25 | 公開日 | 2023-12-13 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11, 2023
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7ACF
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7T79
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![BU of 7t79 by Molmil](/molmil-images/mine/7t79) | |
7T78
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3KDU
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3KDT
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7M2G
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![BU of 7m2g by Molmil](/molmil-images/mine/7m2g) | INTERLEUKIN-2 (human) mutant P65K, C125S | 分子名称: | GLYCEROL, Interleukin-2, SULFATE ION | 著者 | Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M. | 登録日 | 2021-03-16 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism. Nat Commun, 12, 2021
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6IEG
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![BU of 6ieg by Molmil](/molmil-images/mine/6ieg) | Crystal structure of human MTR4 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Exosome RNA helicase MTR4, MAGNESIUM ION | 著者 | Chen, J.Y, Yun, C.H. | 登録日 | 2018-09-14 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | 主引用文献 | NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes Dev., 33, 2019
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6IEH
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![BU of 6ieh by Molmil](/molmil-images/mine/6ieh) | Crystal structures of the hMTR4-NRDE2 complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Exosome RNA helicase MTR4, ... | 著者 | Chen, J.Y, Yun, C.H. | 登録日 | 2018-09-14 | 公開日 | 2019-04-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.892 Å) | 主引用文献 | NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes Dev., 33, 2019
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8G05
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![BU of 8g05 by Molmil](/molmil-images/mine/8g05) | Cryo-EM structure of an orphan GPCR-Gi protein signaling complex | 分子名称: | 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ... | 著者 | Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C. | 登録日 | 2023-01-31 | 公開日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Pro-phagocytic function and structural basis of GPR84 signaling. Nat Commun, 14, 2023
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7N6W
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![BU of 7n6w by Molmil](/molmil-images/mine/7n6w) | Structure of uncleaved HIV-1 JR-FL Env glycoprotein trimer in state U2 bound to small Molecule HIV-1 Entry Inhibitor BMS-378806 | 分子名称: | 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, S, Wang, K, Mao, Y. | 登録日 | 2021-06-09 | 公開日 | 2021-09-22 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer. J.Virol., 95, 2021
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7N6U
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![BU of 7n6u by Molmil](/molmil-images/mine/7n6u) | Structure of uncleaved HIV-1 JR-FL Env glycoprotein trimer in state U1 bound to small Molecule HIV-1 Entry Inhibitor BMS-378806 | 分子名称: | 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, S, Wang, K, Mao, Y. | 登録日 | 2021-06-09 | 公開日 | 2021-09-22 | 最終更新日 | 2021-12-08 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer. J.Virol., 95, 2021
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