6IEG

Crystal structure of human MTR4

Summary for 6IEG

• Entry DOI: 10.2210/pdb6ieg/pdb
• Descriptor: Exosome RNA helicase MTR4, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION (3 entities in total)
• Functional Keywords: rna helicase, mtr4, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 229228.20

Authors

Chen, J.Y.,Yun, C.H. (deposition date: 2018-09-14, release date: 2019-04-03, Last modification date: 2023-11-22)

• Primary citation: Wang, J.,Chen, J.,Wu, G.,Zhang, H.,Du, X.,Chen, S.,Zhang, L.,Wang, K.,Fan, J.,Gao, S.,Wu, X.,Zhang, S.,Kuai, B.,Zhao, P.,Chi, B.,Wang, L.,Li, G.,Wong, C.C.L.,Zhou, Y.,Li, J.,Yun, C.,Cheng, H.; NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.; Genes Dev., 33:536-549, 2019; PubMed: 30842217; DOI: 10.1101/gad.322602.118

Experimental method

X-RAY DIFFRACTION (3.55 Å)