7N6W

Structure of uncleaved HIV-1 JR-FL Env glycoprotein trimer in state U2 bound to small Molecule HIV-1 Entry Inhibitor BMS-378806

Summary for 7N6W

• Entry DOI: 10.2210/pdb7n6w/pdb
• EMDB information: 23861
• Descriptor: Envelope glycoprotein gp160, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: hiv-1, envelope, virus, glycoprotein, viral protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 3
• Total formula weight: 314559.69

Authors

Zhang, S.,Wang, K.,Mao, Y. (deposition date: 2021-06-09, release date: 2021-09-22, Last modification date: 2021-12-08)

• Primary citation: Zhang, S.,Wang, K.,Wang, W.L.,Nguyen, H.T.,Chen, S.,Lu, M.,Go, E.P.,Ding, H.,Steinbock, R.T.,Desaire, H.,Kappes, J.C.,Sodroski, J.,Mao, Y.; Asymmetric Structures and Conformational Plasticity of the Uncleaved Full-Length Human Immunodeficiency Virus Envelope Glycoprotein Trimer.; J.Virol., 95:e0052921-e0052921, 2021; PubMed: 34549974; DOI: 10.1128/JVI.00529-21

Experimental method

ELECTRON MICROSCOPY (4.7 Å)