4PSJ
 
 | | Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium (NESG) Target OR464. | | 分子名称: | OR464 | | 著者 | Vorobiev, S, Parmeggiani, F, Seetharaman, J, Huang, P.-S, Janjua, H, Xiao, R, Maglaqui, M, Park, K, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2014-03-07 | | 公開日 | 2014-03-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | | 主引用文献 | Crystal Structure of Engineered Protein OR464.
To be Published
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6U3Y
 | | Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus | | 分子名称: | ACETATE ION, Gamma-hemolysin subunit A, Panton-Valentine Leucocidin F, ... | | 著者 | Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M. | | 登録日 | 2019-08-22 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
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8A5Y
 | | S. cerevisiae apo unphosphorylated APC/C. | | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ... | | 著者 | Barford, D, Fernandez-Vazquez, E, Zhang, Z, Yang, J. | | 登録日 | 2022-06-16 | | 公開日 | 2022-08-31 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex and comparison to apo unphosphorylated and phosphorylated states
To Be Published
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3VDX
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6S0X
 | | Erythromycin Resistant Staphylococcus aureus 70S ribosome (delta R88 A89 uL22) in complex with erythromycin. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Halfon, Y, Matozv, D, Eyal, Z, Bashan, A, Zimmerman, E, Kjeldgaard, J, Ingmer, H, Yonath, A. | | 登録日 | 2019-06-18 | | 公開日 | 2019-08-21 | | 実験手法 | ELECTRON MICROSCOPY (2.425 Å) | | 主引用文献 | Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant.
Sci Rep, 9, 2019
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3VT2
 | | Crystal structure of Ct1,3Gal43A in complex with isopropy-beta-D-thiogalactoside | | 分子名称: | 1-methylethyl 1-thio-beta-D-galactopyranoside, GLYCEROL, Ricin B lectin | | 著者 | Jiang, D, Fan, J, Wang, X, Zhao, Y, Huang, B, Zhang, X.C. | | 登録日 | 2012-05-18 | | 公開日 | 2012-12-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.002 Å) | | 主引用文献 | Crystal structure of 1,3Gal43A, an exo-beta-1,3-galactanase from Clostridium thermocellum
J.Struct.Biol., 180, 2012
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7SS5
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6UCN
 | | Multi-conformer model of Ketosteroid Isomerase from Pseudomonas Putida (pKSI) bound to Equilenin at 250 K | | 分子名称: | CHLORIDE ION, EQUILENIN, MAGNESIUM ION, ... | | 著者 | Yabukarski, F, Herschlag, D, Biel, J.T, Fraser, J.S. | | 登録日 | 2019-09-16 | | 公開日 | 2020-09-23 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6UF7
 | | S2 symmetric peptide design number 5, Uncle Fester | | 分子名称: | S2-5, Uncle Fester | | 著者 | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | | 登録日 | 2019-09-23 | | 公開日 | 2020-12-02 | | 実験手法 | X-RAY DIFFRACTION (0.8 Å) | | 主引用文献 | Computational design of mixed chirality peptide macrocycles with internal symmetry.
Protein Sci., 29, 2020
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6UF8
 | | S2 symmetric peptide design number 6, London Bridge | | 分子名称: | S2-6, London Bridge | | 著者 | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | | 登録日 | 2019-09-23 | | 公開日 | 2020-12-02 | | 実験手法 | X-RAY DIFFRACTION (0.8 Å) | | 主引用文献 | Computational design of mixed chirality peptide macrocycles with internal symmetry.
Protein Sci., 29, 2020
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7SZ7
 | | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed" conformation | | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | | 登録日 | 2021-11-25 | | 公開日 | 2021-12-15 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Elife, 10, 2021
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7SZ1
 | | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-separated" conformation | | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | | 登録日 | 2021-11-25 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Elife, 10, 2021
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7SYD
 | | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF "tips-juxtaposed" conformation | | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | | 登録日 | 2021-11-24 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Elife, 10, 2021
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6UFU
 | | C2 symmetric peptide design number 1, Zappy, crystal form 1 | | 分子名称: | C2-1, Zappy, crystal form 1 | | 著者 | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | | 登録日 | 2019-09-25 | | 公開日 | 2020-12-02 | | 実験手法 | X-RAY DIFFRACTION (1.101 Å) | | 主引用文献 | Computational design of mixed chirality peptide macrocycles with internal symmetry.
Protein Sci., 29, 2020
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7SZ5
 | | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha "tips-separated" conformation | | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | | 登録日 | 2021-11-25 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Elife, 10, 2021
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7T39
 | | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor | | 分子名称: | 7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Protein arginine N-methyltransferase 9 | | 著者 | Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2021-12-07 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor
To Be Published
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6UG3
 | | C3 symmetric peptide design number 1, Sporty, crystal form 1 | | 分子名称: | C3-1, Sporty, crystal form 1, ... | | 著者 | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | | 登録日 | 2019-09-25 | | 公開日 | 2020-12-02 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Computational design of mixed chirality peptide macrocycles with internal symmetry.
Protein Sci., 29, 2020
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7SYE
 | | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation | | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | | 登録日 | 2021-11-24 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Elife, 10, 2021
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6UGC
 | | C3 symmetric peptide design number 3 | | 分子名称: | C3-3 cyclic peptide design, CADMIUM ION, SODIUM ION | | 著者 | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | | 登録日 | 2019-09-26 | | 公開日 | 2020-12-02 | | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | | 主引用文献 | Computational design of mixed chirality peptide macrocycles with internal symmetry.
Protein Sci., 29, 2020
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7SZ0
 | | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-juxtaposed" conformation | | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | | 登録日 | 2021-11-25 | | 公開日 | 2021-12-22 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Elife, 10, 2021
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7T3X
 | | Structure of unphosphorylated Pediculus humanus (Ph) PINK1 D334A mutant | | 分子名称: | Serine/threonine-protein kinase PINK1 | | 著者 | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | 登録日 | 2021-12-09 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | | 主引用文献 | Activation mechanism of PINK1.
Nature, 602, 2022
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8A61
 | | S. cerevisiae apo phosphorylated APC/C | | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ... | | 著者 | Barford, D, Fernandez-Vazquez, E, Zhang, Z, Yang, J. | | 登録日 | 2022-06-16 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | | 主引用文献 | Cryo-EM structure of the S. cerevisiae apo phosphorylated APC/C
To Be Published
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7T71
 | | Crystal Structure of Mevalonate 3,5-Bisphosphate Decarboxylase from Picrophilus Torridus | | 分子名称: | Mevalonate 3,5-bisphosphate decarboxylase, OLEIC ACID | | 著者 | Vinokur, J.M, Sawaya, M.R, Cascio, D, Collazo, M, Bowie, J.U. | | 登録日 | 2021-12-14 | | 公開日 | 2021-12-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways.
J.Biol.Chem., 298, 2022
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8A3T
 | | S. cerevisiae APC/C-Cdh1 complex | | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Anaphase-promoting complex subunit 2, ... | | 著者 | Barford, D, Vazquez-Fernandez, E, Zhang, Z, Yang, J. | | 登録日 | 2022-06-09 | | 公開日 | 2022-08-31 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex
To Be Published
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6UKS
 | | ATPgammaS bound mBcs1 | | 分子名称: | MAGNESIUM ION, Mitochondrial chaperone BCS1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | 著者 | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | | 登録日 | 2019-10-05 | | 公開日 | 2020-02-05 | | 最終更新日 | 2020-02-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
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