7T39

Co-crystal structure of human PRMT9 in complex with MT221 inhibitor

Summary for 7T39

• Entry DOI: 10.2210/pdb7t39/pdb
• Descriptor: Protein arginine N-methyltransferase 9, 7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total)
• Functional Keywords: methyltransferase, prmt9, sgc, structural genomics, structural genomics consortium, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 80958.90

Authors

Zeng, H.,Dong, A.,Hutchinson, A.,Seitova, A.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (deposition date: 2021-12-07, release date: 2021-12-22, Last modification date: 2023-10-18)

• Primary citation: Zeng, H.,Dong, A.,Hutchinson, A.,Seitova, A.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Co-crystal structure of human PRMT9 in complex with MT221 inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.81 Å)