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6B7Z
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BU of 6b7z by Molmil
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain
分子名称: FAB H11 heavy chain, FAB H11 light chain, Insulin-degrading enzyme
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-10-05
公開日2018-01-10
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BF9
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BU of 6bf9 by Molmil
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain
分子名称: Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-10-26
公開日2018-02-07
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (7.2 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
2JG4
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BU of 2jg4 by Molmil
Substrate-free IDE structure in its closed conformation
分子名称: 1,4-DIETHYLENE DIOXIDE, INSULIN DEGRADING ENZYME, ZINC ION
著者Malito, E, Tang, W.J.
登録日2007-02-07
公開日2007-07-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
2JE4
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BU of 2je4 by Molmil
Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365
分子名称: ACETATE ION, GLYCEROL, INHIBITOR MOLECULE JG365, ...
著者Malito, E, Johnson, E.C.B, Tang, W.J.
登録日2007-01-15
公開日2007-08-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Modular Total Chemical Synthesis of a Human Immunodeficiency Virus Type 1 Protease.
J.Am.Chem.Soc., 129, 2007
6BF7
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BU of 6bf7 by Molmil
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain
分子名称: Fab H11-E heavy chain, Fab H11-E light chain, Insulin-degrading enzyme
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-10-26
公開日2018-02-07
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
2JBU
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BU of 2jbu by Molmil
Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.
分子名称: 1,4-DIETHYLENE DIOXIDE, CO-PURIFIED PEPTIDE, INSULIN-DEGRADING ENZYME
著者Im, H, Shen, Y, Tang, W.J.
登録日2006-12-11
公開日2007-07-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
6B70
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BU of 6b70 by Molmil
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11-E heavy chain, FAB H11-E light chain and insulin
分子名称: FAB H11-E heavy chain, FAB H11-E light chain, Insulin, ...
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-10-03
公開日2017-12-27
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6B7Y
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BU of 6b7y by Molmil
Cryo-EM structure of human insulin degrading enzyme
分子名称: Insulin-degrading enzyme
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-10-05
公開日2017-11-08
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6BFC
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BU of 6bfc by Molmil
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
分子名称: Insulin, Insulin-degrading enzyme
著者Liang, W.G, Zhang, Z, Bailey, L.J, Kossiakoff, A.A, Tan, Y.Z, Wei, H, Carragher, B, Potter, S.C, Tang, W.J.
登録日2017-10-26
公開日2017-12-27
最終更新日2021-04-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
6C6D
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BU of 6c6d by Molmil
20mer crystal structure of CC chemokine 5 (CCL5)
分子名称: C-C motif chemokine 5
著者Liang, W.G, Tang, W.J.
登録日2018-01-18
公開日2019-01-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (5.5 Å)
主引用文献20mer crystal structure of CC chemokine 5 (CCL5)
To Be Published
5D65
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BU of 5d65 by Molmil
X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) WITH HEPARIN COMPLEX
分子名称: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, C-C motif chemokine 3, CHLORIDE ION, ...
著者Liang, W.G, Hwang, D.Y, Zulueta, M.M, Hung, S.C, Tang, W.
登録日2015-08-11
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
3E50
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BU of 3e50 by Molmil
Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha
分子名称: Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION
著者Guo, Q, Manolopoulou, M, Tang, W.-J.
登録日2008-08-12
公開日2009-08-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
4IFH
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BU of 4ifh by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
分子名称: Insulin-degrading enzyme, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide, ZINC ION
著者Liang, W.G, Guo, Q, Deprez, R, Deprez, B, Tang, W.
登録日2012-12-14
公開日2013-12-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.286 Å)
主引用文献Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
6XOS
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BU of 6xos by Molmil
CryoEM structure of human presequence protease in partial open state 1
分子名称: Presequence protease, mitochondrial
著者Liang, W.G, Zhao, M, Tang, W.
登録日2020-07-07
公開日2021-07-07
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
6XOU
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BU of 6xou by Molmil
CryoEM structure of human presequence protease in open state
分子名称: Presequence protease, mitochondrial
著者Liang, W.G, Zhao, M, Tang, W.
登録日2020-07-07
公開日2021-07-07
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
6XOV
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BU of 6xov by Molmil
CryoEM structure of human presequence protease in partial closed state 1
分子名称: Amyloid-beta precursor protein, Presequence protease, mitochondrial
著者Liang, W.G, Zhao, M, Tang, W.
登録日2020-07-07
公開日2021-07-07
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
6XOT
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BU of 6xot by Molmil
CryoEM structure of human presequence protease in partial open state 2
分子名称: Presequence protease, mitochondrial
著者Liang, W.G, Zhao, M, Tang, W.
登録日2020-07-07
公開日2021-07-07
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition.
Nat Commun, 13, 2022
6XLY
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BU of 6xly by Molmil
CRYOEM STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ZINC METALLOPROTEASE ZMP1 IN OPEN STATE
分子名称: Probable zinc metalloprotease Zmp1, ZINC ION
著者Liang, W.G, Zhao, M, Tang, W.
登録日2020-06-29
公開日2020-12-23
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states.
Structure, 29, 2021
7K1V
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BU of 7k1v by Molmil
Partial open state of Mycobacterium tuberculosis zinc metalloprotease 1
分子名称: Zinc metalloprotease
著者Mancl, J.M, Liang, W.G, Zhao, M, Tang, W.
登録日2020-09-08
公開日2020-12-23
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states.
Structure, 29, 2021
5COR
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BU of 5cor by Molmil
X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) N-TERMINAL-SWITCH POLYMER
分子名称: ACETATE ION, C-C motif chemokine 3, HEXANE-1,6-DIOL
著者Liang, W.G, Tang, W.
登録日2015-07-20
公開日2016-04-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.548 Å)
主引用文献Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Proc.Natl.Acad.Sci.USA, 113, 2016
3E4Z
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BU of 3e4z by Molmil
Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II
分子名称: Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION
著者Guo, Q, Manolopoulou, M, Tang, W.-J.
登録日2008-08-12
公開日2009-08-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
2G54
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BU of 2g54 by Molmil
Crystal structure of Zn-bound human insulin-degrading enzyme in complex with insulin B chain
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, ZINC ION, ...
著者Shen, Y, Tang, W.-J.
登録日2006-02-22
公開日2006-10-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G47
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BU of 2g47 by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, amyloid protein beta A4
著者Shen, Y, Tang, W.-J.
登録日2006-02-21
公開日2006-10-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G48
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BU of 2g48 by Molmil
crystal structure of human insulin-degrading enzyme in complex with amylin
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, Islet amyloid polypeptide
著者Shen, Y, Tang, W.-J.
登録日2006-02-21
公開日2006-10-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G56
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BU of 2g56 by Molmil
crystal structure of human insulin-degrading enzyme in complex with insulin B chain
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin, Insulin-degrading enzyme
著者Shen, Y, Tang, W.-J.
登録日2006-02-22
公開日2006-10-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006

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