3EN7
 
 | | Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with S1, a multitargeted kinase inhibitor | | 分子名称: | 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Blair, J.A, Apsel, B, Knight, Z.A, Shokat, K.M. | | 登録日 | 2008-09-25 | | 公開日 | 2008-10-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Nat.Chem.Biol., 4, 2008
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3G6Z
 | | Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors | | 分子名称: | (1R,5S)-N-cyclopropyl-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin | | 著者 | Bezencon, O, Bur, D, Prade, L, Weller, T, Boss, C, Fischli, W. | | 登録日 | 2009-02-09 | | 公開日 | 2009-06-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors
J.Med.Chem., 52, 2009
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5D79
 | | Structure of BBE-like #28 from Arabidopsis thaliana | | 分子名称: | Berberine bridge enzyme-like protein, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Daniel, B, Kumar, P, Gruber, K. | | 登録日 | 2015-08-13 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | | 主引用文献 | Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae.
Plos One, 11, 2016
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3G72
 | | Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors | | 分子名称: | (1S,5R)-7-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | 著者 | Bezencon, O, Bur, D, Prade, L, Weller, T, Boss, C, Fischli, W. | | 登録日 | 2009-02-09 | | 公開日 | 2009-06-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors
J.Med.Chem., 52, 2009
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3G70
 | | Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors | | 分子名称: | (1R,5S)-7-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | | 著者 | Bezencon, O, Bur, D, Prade, L, Weller, T, Boss, C, Fischli, W. | | 登録日 | 2009-02-09 | | 公開日 | 2009-06-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors
J.Med.Chem., 52, 2009
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8QSQ
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8QQI
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6O9C
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6OFE
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6OFG
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6OFF
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6O9B
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6OFH
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5F5W
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6UJ8
 | | Crystal structure of HLA-B*07:02 with wild-type IDH2 peptide | | 分子名称: | Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, HLA class I histocompatibility antigen, ... | | 著者 | Miller, M.S, Thirawatananond, P, Gabelli, S.B. | | 登録日 | 2019-10-02 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
Nat Commun, 12, 2021
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6UJ9
 | | Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide in complex with Fab | | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Miller, M.S, Thirawatananond, P, Aytenfisu, T.Y, Wright, K, Gabelli, S.B. | | 登録日 | 2019-10-02 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
Nat Commun, 12, 2021
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6UJ7
 | | Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-7 alpha chain, ... | | 著者 | Miller, M.S, Thirawatananond, P, Gabelli, S.B. | | 登録日 | 2019-10-02 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.
Nat Commun, 12, 2021
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6W51
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8QRG
 | | SARS-CoV-2 delta RBD complexed with XBB-2 Fab and NbC1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, NbC1, ... | | 著者 | Zhou, D, Ren, J, Stuart, D.I. | | 登録日 | 2023-10-07 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Cell Rep Med, 5, 2024
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8QX9
 | | TDP-43 amyloid fibrils: Morphology-1a | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Sharma, K, Shenoy, J, Loquet, A, Schmidt, M, Faendrich, M. | | 登録日 | 2023-10-24 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | | 主引用文献 | Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils.
Nat Commun, 15, 2024
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8QTD
 | | Local refinement of SARS-CoV-2 BA.2.86 Spike and XBB-7 Fab | | 分子名称: | Spike glycoprotein,Fibritin, XBB-7 fab heavy chain, XBB-7 fab light chain | | 著者 | Ren, J, Duyvesteyn, H.M.E, Stuart, D.I. | | 登録日 | 2023-10-12 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Cell Rep Med, 5, 2024
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8QRF
 | | SARS-CoV-2 delta RBD complexed with XBB-6 and beta-49 Fabs | | 分子名称: | Beta-49 heavy chain, Beta-49 light chain, Spike protein S1, ... | | 著者 | Zhou, D, Ren, J, Stuart, D.I. | | 登録日 | 2023-10-06 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Cell Rep Med, 5, 2024
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8R80
 | | SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody | | 分子名称: | Spike protein S1, XBB-9 Fab heavy chain, XBB-9 Fab light chain, ... | | 著者 | Zhou, D, Ren, J, Stuart, D.I. | | 登録日 | 2023-11-27 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (4.03 Å) | | 主引用文献 | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Cell Rep Med, 5, 2024
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8R8K
 | | XBB-4 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein | | 分子名称: | Spike glycoprotein,Fibritin, XBB-4 Fab Heavy chain, XBB-4 Fab Light chain | | 著者 | Duyvesteyn, H.M.E, Ren, J, Stuart, D.I. | | 登録日 | 2023-11-29 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Cell Rep Med, 5, 2024
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8QXB
 | | TDP-43 amyloid fibrils: Morphology-2 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Sharma, K, Shenoy, J, Loquet, A, Schmidt, M, Faendrich, M. | | 登録日 | 2023-10-24 | | 公開日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | | 主引用文献 | Cryo-EM observation of the amyloid key structure of polymorphic TDP-43 amyloid fibrils.
Nat Commun, 15, 2024
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