8R8K

XBB-4 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein

Summary for 8R8K

• Entry DOI: 10.2210/pdb8r8k/pdb
• Related: 8CIN 8QTD 8R1C 8R1D
• EMDB information: 19002
• Descriptor: Spike glycoprotein, XBB-4 Fab Heavy chain, XBB-4 Fab Light chain (3 entities in total)
• Functional Keywords: sars-cov-2, spike, glycoprotein, coronavirus, antibody, fab, xbb.1.5, therapeutic, complex, neutralising, rbd, receptor binding domain, convalescent sera, viral protein, immune system, xbb-4, ba.2.12.1, omicron variant, virus, ba.2.86
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 3
• Total formula weight: 190670.66

Authors

Duyvesteyn, H.M.E.,Ren, J.,Stuart, D.I. (deposition date: 2023-11-29, release date: 2024-05-08, Last modification date: 2024-06-05)

• Primary citation: Liu, C.,Zhou, D.,Dijokaite-Guraliuc, A.,Supasa, P.,Duyvesteyn, H.M.E.,Ginn, H.M.,Selvaraj, M.,Mentzer, A.J.,Das, R.,de Silva, T.I.,Ritter, T.G.,Plowright, M.,Newman, T.A.H.,Stafford, L.,Kronsteiner, B.,Temperton, N.,Lui, Y.,Fellermeyer, M.,Goulder, P.,Klenerman, P.,Dunachie, S.J.,Barton, M.I.,Kutuzov, M.A.,Dushek, O.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R.; A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.; Cell Rep Med, 5:101553-101553, 2024; PubMed: 38723626; DOI: 10.1016/j.xcrm.2024.101553

Experimental method

ELECTRON MICROSCOPY (3.41 Å)