6W51

Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H

Summary for 6W51

• Entry DOI: 10.2210/pdb6w51/pdb
• Descriptor: MHC class I antigen, Beta-2-microglobulin, Cellular tumor antigen p53 peptide, ... (7 entities in total)
• Functional Keywords: immunotherapy, mhc-i, hla-a2, p53, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 20
• Total formula weight: 386132.70

Authors

Wright, K.M.,Gabelli, S.B. (deposition date: 2020-03-12, release date: 2021-03-17, Last modification date: 2023-10-18)

• Primary citation: Hsiue, E.H.,Wright, K.M.,Douglass, J.,Hwang, M.S.,Mog, B.J.,Pearlman, A.H.,Paul, S.,DiNapoli, S.R.,Konig, M.F.,Wang, Q.,Schaefer, A.,Miller, M.S.,Skora, A.D.,Azurmendi, P.A.,Murphy, M.B.,Liu, Q.,Watson, E.,Li, Y.,Pardoll, D.M.,Bettegowda, C.,Papadopoulos, N.,Kinzler, K.W.,Vogelstein, B.,Gabelli, S.B.,Zhou, S.; Targeting a neoantigen derived from a common TP53 mutation.; Science, 371:-, 2021; PubMed: 33649166; DOI: 10.1126/science.abc8697

Experimental method

X-RAY DIFFRACTION (3.53 Å)