6W51
Structure of the antibody fragment H2 in complex with HLA-A*02:01/p53R175H
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D, G, J | MHC class I antigen | polymer | 296 | 34183.7 | 4 | UniProt (U5YKE0) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (A0A140T913) In PDB | Homo sapiens (Human) | |
2 | B, E, H, K | Beta-2-microglobulin | polymer | 119 | 13732.5 | 4 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C, F, I, L | Cellular tumor antigen p53 peptide | polymer | 9 | 1114.3 | 4 | UniProt (P04637) In PDB | Homo sapiens | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
4 | M, O, Q, S | Immunoglobulin heavy chain H2 | polymer | 223 | 23780.5 | 4 | Homo sapiens (Human) | ||
5 | N, P, R, T | Immunoglobulin light chain H2 | polymer | 215 | 23698.3 | 4 | Homo sapiens (Human) | ||
6 | S | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
7 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, D, G, J: 1 - 276 (UniProt: U5YKE0)
C, F, I, L: 1 - 9 (UniProt: P04637)
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
Gly 277 | - | expression tag |
Ser 278 | - | expression tag |
Gly 279 | - | expression tag |
Ser 280 | - | expression tag |
Gly 281 | - | expression tag |
Leu 282 | - | expression tag |
Asn 283 | - | expression tag |
Asp 284 | - | expression tag |
Ile 285 | - | expression tag |
Phe 286 | - | expression tag |
Glu 287 | - | expression tag |
Ala 288 | - | expression tag |
Gln 289 | - | expression tag |
Lys 290 | - | expression tag |
Ile 291 | - | expression tag |
Glu 292 | - | expression tag |
Trp 293 | - | expression tag |
His 294 | - | expression tag |
Glu 295 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 8 | Arg 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 20 |
Total formula weight | 386037.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 95.0 | |
All* | Total formula weight | 386132.7 |