8R80

SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody

Summary for 8R80

• Entry DOI: 10.2210/pdb8r80/pdb
• Related: 8QRF 8QRG 8QSQ 8QTD
• Descriptor: XBB-9 Fab heavy chain, XBB-9 Fab light chain, Spike protein S1, ... (4 entities in total)
• Functional Keywords: sars-cov-2, rbd, ba.2.86, xbb.1.5, xbb.1.5.10, xbb.1.5.70, viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 8
• Total formula weight: 169573.34

Authors

Zhou, D.,Ren, J.,Stuart, D.I. (deposition date: 2023-11-27, release date: 2024-05-08, Last modification date: 2024-10-23)

Primary citation

Liu, C.,Zhou, D.,Dijokaite-Guraliuc, A.,Supasa, P.,Duyvesteyn, H.M.E.,Ginn, H.M.,Selvaraj, M.,Mentzer, A.J.,Das, R.,de Silva, T.I.,Ritter, T.G.,Plowright, M.,Newman, T.A.H.,Stafford, L.,Kronsteiner, B.,Temperton, N.,Lui, Y.,Fellermeyer, M.,Goulder, P.,Klenerman, P.,Dunachie, S.J.,Barton, M.I.,Kutuzov, M.A.,Dushek, O.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R.
A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity.
Cell Rep Med, 5:101553-101553, 2024

PubMed Abstract: BA.2.86, a recently described sublineage of SARS-CoV-2 Omicron, contains many mutations in the spike gene. It appears to have originated from BA.2 and is distinct from the XBB variants responsible for many infections in 2023. The global spread and plethora of mutations in BA.2.86 has caused concern that it may possess greater immune-evasive potential, leading to a new wave of infection. Here, we examine the ability of BA.2.86 to evade the antibody response to infection using a panel of vaccinated or naturally infected sera and find that it shows marginally less immune evasion than XBB.1.5. We locate BA.2.86 in the antigenic landscape of recent variants and look at its ability to escape panels of potent monoclonal antibodies generated against contemporary SARS-CoV-2 infections. We demonstrate, and provide a structural explanation for, increased affinity of BA.2.86 to ACE2, which may increase transmissibility.

PubMed: 38723626
DOI: 10.1016/j.xcrm.2024.101553

Experimental method

X-RAY DIFFRACTION (4.03 Å)