8QQI

E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800

Summary for 8QQI

Entry DOI	10.2210/pdb8qqi/pdb
EMDB information	18592
Descriptor	DNA gyrase subunit A, DNA gyrase subunit B, Mu217 chain E, ... (6 entities in total)
Functional Keywords	topoisomerase, gyrase, allosteric inhibitor, antibiotic, dna binding protein
Biological source	Escherichia coli More
Total number of polymer chains	6
Total formula weight	313843.23
Authors	Ghilarov, D.,Martin, N.I.,van der Stelt, M. (deposition date: 2023-10-04, release date: 2024-06-19, Last modification date: 2024-07-03)
Primary citation	Bakker, A.T.,Kotsogianni, I.,Avalos, M.,Punt, J.M.,Liu, B.,Piermarini, D.,Gagestein, B.,Slingerland, C.J.,Zhang, L.,Willemse, J.J.,Ghimire, L.B.,van den Berg, R.J.H.B.N.,Janssen, A.P.A.,Ottenhoff, T.H.M.,van Boeckel, C.A.A.,van Wezel, G.P.,Ghilarov, D.,Martin, N.I.,van der Stelt, M. Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria. Nat.Chem., 2024 Cited by PubMed: 38898213 DOI: 10.1038/s41557-024-01516-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation