8QQI

E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003916	molecular_function	DNA topoisomerase activity
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006261	biological_process	DNA-templated DNA replication
B	0006265	biological_process	DNA topological change
B	0006351	biological_process	DNA-templated transcription
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0009330	cellular_component	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
B	0009410	biological_process	response to xenobiotic stimulus
B	0016853	molecular_function	isomerase activity
B	0034335	molecular_function	DNA negative supercoiling activity
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0051276	biological_process	chromosome organization
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006265	biological_process	DNA topological change
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003916	molecular_function	DNA topoisomerase activity
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006261	biological_process	DNA-templated DNA replication
D	0006265	biological_process	DNA topological change
D	0006351	biological_process	DNA-templated transcription
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0009330	cellular_component	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
D	0009410	biological_process	response to xenobiotic stimulus
D	0016853	molecular_function	isomerase activity
D	0034335	molecular_function	DNA negative supercoiling activity
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
D	0051276	biological_process	chromosome organization

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU422-GLY430

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	230
Details	Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12051843","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18642932","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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