3G6Z
Design and Preparation of Potent, Non-Peptidic, Bioavailable Renin Inhibitors
Summary for 3G6Z
Entry DOI | 10.2210/pdb3g6z/pdb |
Related | 3d91 3g70 3g72 |
Descriptor | Renin, (1R,5S)-N-cyclopropyl-7-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-N-(2,3-dimethylbenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | renin human, aspartyl protease, cleavage on pair of basic residues, disease mutation, glycoprotein, hydrolase, membrane, protease, secreted, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76715.14 |
Authors | Bezencon, O.,Bur, D.,Prade, L.,Weller, T.,Boss, C.,Fischli, W. (deposition date: 2009-02-09, release date: 2009-06-30, Last modification date: 2020-07-29) |
Primary citation | Bezencon, O.,Bur, D.,Weller, T.,Richard-Bildstein, S.,Remen, L.,Sifferlen, T.,Corminboeuf, O.,Grisostomi, C.,Boss, C.,Prade, L.,Delahaye, S.,Treiber, A.,Strickner, P.,Binkert, C.,Hess, P.,Steiner, B.,Fischli, W. Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors J.Med.Chem., 52:3689-3702, 2009 Cited by PubMed: 19358611DOI: 10.1021/jm900022f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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