6UJ7

Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide

Summary for 6UJ7

• Entry DOI: 10.2210/pdb6uj7/pdb
• Descriptor: HLA class I histocompatibility antigen, B-7 alpha chain, Beta-2-microglobulin, Isocitrate dehydrogenase [NADP], mitochondrial, ... (7 entities in total)
• Functional Keywords: hla-b7, mhc-i, immunotherapy, idh2, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 98999.63

Authors

Miller, M.S.,Thirawatananond, P.,Gabelli, S.B. (deposition date: 2019-10-02, release date: 2021-05-05, Last modification date: 2023-10-11)

• Primary citation: Hwang, M.S.,Miller, M.S.,Thirawatananond, P.,Douglass, J.,Wright, K.M.,Hsiue, E.H.,Mog, B.J.,Aytenfisu, T.Y.,Murphy, M.B.,Aitana Azurmendi, P.,Skora, A.D.,Pearlman, A.H.,Paul, S.,DiNapoli, S.R.,Konig, M.F.,Bettegowda, C.,Pardoll, D.M.,Papadopoulos, N.,Kinzler, K.W.,Vogelstein, B.,Zhou, S.,Gabelli, S.B.; Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens.; Nat Commun, 12:5271-5271, 2021; PubMed: 34489470; DOI: 10.1038/s41467-021-25605-4

Experimental method

X-RAY DIFFRACTION (1.9 Å)