6UJ7

Crystal structure of HLA-B*07:02 with R140Q mutant IDH2 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	HLA class I histocompatibility antigen, B-7 alpha chain	polymer	298	34609.0	2	UniProt (P01889) Pfam (PF00129) Pfam (PF07654)	Homo sapiens (Human)	MHC class I antigen B*7
2	B, E (B, E)	Beta-2-microglobulin	polymer	119	13732.5	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	C, F (C, F)	Isocitrate dehydrogenase [NADP], mitochondrial	polymer	10	1056.2	2	UniProt (P48735)	Homo sapiens	IDH,ICD-M,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase
4	G (A)	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
5	H, I, J (A, B, D)	SODIUM ION	non-polymer		23.0	3	Chemie (NA)
6	K (D)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
7	L, M, N, O, P... (A, B, C, D, E...)	water	water		18.0	496	Chemie (HOH)

Sequence modifications

A, D: 1 - 280 (UniProt: P01889)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 281	-	expression tag
Ser 282	-	expression tag
Leu 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
Ile 286	-	expression tag
Leu 287	-	expression tag
Asp 288	-	expression tag
Ala 289	-	expression tag
Gln 290	-	expression tag
Lys 291	-	expression tag
Met 292	-	expression tag
Val 293	-	expression tag
Trp 294	-	expression tag
Asn 295	-	expression tag
His 296	-	expression tag
Arg 297	-	expression tag

C, F: 1 - 10 (UniProt: P48735)

PDB	External Database	Details
Gln 7	Arg 140	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	98795.5
Non-Polymers*	Number of molecules	5
	Total formula weight	204.1
All*	Total formula weight	98999.6

*Water molecules are not included.