5HN9
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4EA1
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![BU of 4ea1 by Molmil](/molmil-images/mine/4ea1) | Co-crystal structure of dehydrosqualene synthase (Crtm) from S. aureus with SQ-109 | 分子名称: | Dehydrosqualene synthase, N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine | 著者 | Lin, F.-Y, Li, K, Liu, Y.-L, Oldfield, E. | 登録日 | 2012-03-21 | 公開日 | 2012-04-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets. J.Med.Chem., 55, 2012
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4GA3
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![BU of 4ga3 by Molmil](/molmil-images/mine/4ga3) | Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260 | 分子名称: | 1-butyl-3-(2-hydroxy-2,2-diphosphonoethyl)-1H-imidazol-3-ium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... | 著者 | Liu, Y.-L, Zhang, Y, Oldfield, E. | 登録日 | 2012-07-24 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis. ACS MED.CHEM.LETT., 4, 2013
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4F6X
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![BU of 4f6x by Molmil](/molmil-images/mine/4f6x) | Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1112 | 分子名称: | 1-[3-(hexyloxy)benzyl]-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid, D(-)-TARTARIC ACID, Dehydrosqualene synthase, ... | 著者 | Lin, F.-Y, Zhang, Y, Liu, Y.-L, Oldfield, E. | 登録日 | 2012-05-15 | 公開日 | 2012-06-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3, 2012
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4EA0
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![BU of 4ea0 by Molmil](/molmil-images/mine/4ea0) | Crystal structure of dehydrosqualene synthase (Crtm) from S. aureus complexed with diphosphate and quinuclidine BPH-651 | 分子名称: | (3R)-3-biphenyl-4-yl-1-azabicyclo[2.2.2]octan-3-ol, Dehydrosqualene synthase, L(+)-TARTARIC ACID, ... | 著者 | Lin, F.-Y, Liu, Y.-L, Oldfield, E. | 登録日 | 2012-03-21 | 公開日 | 2012-04-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets. J.Med.Chem., 55, 2012
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4E9U
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![BU of 4e9u by Molmil](/molmil-images/mine/4e9u) | Crystal structure of dehydrosqualene synthase (Crtm) from S. aureus complexed with a thiocyanate inhibitor | 分子名称: | 2-(4-phenoxyphenoxy)ethyl thiocyanate, Dehydrosqualene synthase, MAGNESIUM ION | 著者 | Lin, F.-Y, Axelson, J, Liu, Y.-L, Zhnag, Y, Oldfield, E. | 登録日 | 2012-03-21 | 公開日 | 2012-04-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets. J.Med.Chem., 55, 2012
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4E9Z
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4EA2
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![BU of 4ea2 by Molmil](/molmil-images/mine/4ea2) | Crystal structure of dehydrosqualene synthase (Crtm) aureus complexed with SQ-109 | 分子名称: | Dehydrosqualene synthase, MAGNESIUM ION, N-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, ... | 著者 | Lin, F.-Y, Li, K, Liu, Y.-L, Oldfield, E. | 登録日 | 2012-03-21 | 公開日 | 2012-04-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets. J.Med.Chem., 55, 2012
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4F6V
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![BU of 4f6v by Molmil](/molmil-images/mine/4f6v) | Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1034, mg2+ and fmp. | 分子名称: | (2E,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl dihydrogen phosphate, 2,4-dioxo-4-{[3-(3-phenoxyphenyl)propyl]amino}butanoic acid, Dehydrosqualene synthase, ... | 著者 | Lin, F.-Y, Zhang, Y, Liu, Y.-L, Oldfield, E. | 登録日 | 2012-05-15 | 公開日 | 2012-06-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3, 2012
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3TH8
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![BU of 3th8 by Molmil](/molmil-images/mine/3th8) | Structure of E. coli undecaprenyl diphosphate synthase complexed with BPH-1063 | 分子名称: | (2Z)-4-({3-[3-(hexyloxy)phenyl]propyl}amino)-2-hydroxy-4-oxobut-2-enoic acid, Undecaprenyl pyrophosphate synthase | 著者 | Cao, R, Zhu, W, Zhang, Y, Oldfield, E. | 登録日 | 2011-08-18 | 公開日 | 2012-07-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.114 Å) | 主引用文献 | HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3, 2012
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3WCA
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![BU of 3wca by Molmil](/molmil-images/mine/3wca) | The complex structure of TcSQS with ligand, FSPP | 分子名称: | Farnesyltransferase, putative, MAGNESIUM ION, ... | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Oldfield, E, Guo, R.T. | 登録日 | 2013-05-26 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCH
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![BU of 3wch by Molmil](/molmil-images/mine/3wch) | The complex structure of HsSQS wtih ligand BPH1237 | 分子名称: | Squalene synthase, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCD
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![BU of 3wcd by Molmil](/molmil-images/mine/3wcd) | The complex structure of HsSQS wtih ligand, WC-9 | 分子名称: | 2-(4-phenoxyphenoxy)ethyl thiocyanate, Squalene synthase | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCB
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![BU of 3wcb by Molmil](/molmil-images/mine/3wcb) | The complex structure of TcSQS with ligand, BPH1237 | 分子名称: | Farnesyltransferase, putative, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCL
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![BU of 3wcl by Molmil](/molmil-images/mine/3wcl) | The complex structure of HsSQS wtih ligand,BPH1344 | 分子名称: | Squalene synthase, hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-28 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCI
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![BU of 3wci by Molmil](/molmil-images/mine/3wci) | The complex structure of HsSQS wtih ligand,BPH1325 | 分子名称: | Squalene synthase, hydrogen [(1R)-1-hydroxy-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCG
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![BU of 3wcg by Molmil](/molmil-images/mine/3wcg) | The complex structure of TcSQS with ligand, BPH1344 | 分子名称: | Farnesyltransferase, putative, hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCE
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![BU of 3wce by Molmil](/molmil-images/mine/3wce) | The complex structure of TcSQS with ligand, ER119884 | 分子名称: | (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol, Farnesyltransferase, putative | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WC9
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![BU of 3wc9 by Molmil](/molmil-images/mine/3wc9) | The complex structure of HsSQS wtih ligand, FSPP | 分子名称: | S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-26 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCM
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![BU of 3wcm by Molmil](/molmil-images/mine/3wcm) | The complex structure of HsSQS wtih ligand, ER119884 | 分子名称: | (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol, Squalene synthase | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-28 | 公開日 | 2014-06-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCF
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![BU of 3wcf by Molmil](/molmil-images/mine/3wcf) | The complex structure of HsSQS wtih ligand,BPH1218 | 分子名称: | Squalene synthase, hydrogen [(1S)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCJ
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![BU of 3wcj by Molmil](/molmil-images/mine/3wcj) | The complex structure of HsSQS wtih ligand,E5700 | 分子名称: | (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol, Squalene synthase | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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3WCC
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![BU of 3wcc by Molmil](/molmil-images/mine/3wcc) | The complex structure of TcSQS with ligand, E5700 | 分子名称: | (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol, Farnesyltransferase, putative | 著者 | Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. | 登録日 | 2013-05-27 | 公開日 | 2014-06-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
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4H2J
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4H3A
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![BU of 4h3a by Molmil](/molmil-images/mine/4h3a) | |