4GA3
Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260
Summary for 4GA3
Entry DOI | 10.2210/pdb4ga3/pdb |
Descriptor | Farnesyl pyrophosphate synthase, 1-butyl-3-(2-hydroxy-2,2-diphosphonoethyl)-1H-imidazol-3-ium, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | all alpha helices, cytosol, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 40621.75 |
Authors | Liu, Y.-L.,Zhang, Y.,Oldfield, E. (deposition date: 2012-07-24, release date: 2013-05-08, Last modification date: 2023-09-13) |
Primary citation | Zhang, Y.,Zhu, W.,Liu, Y.L.,Wang, H.,Wang, K.,Li, K.,No, J.H.,Ayong, L.,Gulati, A.,Pang, R.,Freitas-Junior, L.,Morita, C.T.,Old-Field, E. Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis. ACS MED.CHEM.LETT., 4:423-427, 2013 Cited by PubMed: 23610597DOI: 10.1021/ml4000436 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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