3WCJ
The complex structure of HsSQS wtih ligand,E5700
Summary for 3WCJ
Entry DOI | 10.2210/pdb3wcj/pdb |
Related | 3WC9 3WCA 3WCB 3WCC 3WCD 3WCE 3WCF 3WCG 3WCH 3WCI 3WCL 3WCM |
Descriptor | Squalene synthase, (3R)-3-({2-benzyl-6-[(3R,4S)-3-hydroxy-4-methoxypyrrolidin-1-yl]pyridin-3-yl}ethynyl)-1-azabicyclo[2.2.2]octan-3-ol (3 entities in total) |
Functional Keywords | isoprenoids, drug discovery, human squalene synthase, transferase, e5700 |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268 |
Total number of polymer chains | 6 |
Total formula weight | 250335.19 |
Authors | Shang, N.,Li, Q.,Ko, T.P.,Chan, H.C.,Huang, C.H.,Ren, F.,Zheng, Y.,Zhu, Z.,Chen, C.C.,Guo, R.T. (deposition date: 2013-05-27, release date: 2014-06-18, Last modification date: 2023-11-08) |
Primary citation | Shang, N.,Li, Q.,Ko, T.P.,Chan, H.C.,Li, J.,Zheng, Y.,Huang, C.H.,Ren, F.,Chen, C.C.,Zhu, Z.,Galizzi, M.,Li, Z.H.,Rodrigues-Poveda, C.A.,Gonzalez-Pacanowska, D.,Veiga-Santos, P.,de Carvalho, T.M.,de Souza, W.,Urbina, J.A.,Wang, A.H.,Docampo, R.,Li, K.,Liu, Y.L.,Oldfield, E.,Guo, R.T. Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10:e1004114-e1004114, 2014 Cited by PubMed: 24789335DOI: 10.1371/journal.ppat.1004114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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