4EA1
Co-crystal structure of dehydrosqualene synthase (Crtm) from S. aureus with SQ-109
Summary for 4EA1
| Entry DOI | 10.2210/pdb4ea1/pdb |
| Related | 4E9U 4E9Z 4EA0 4EA2 |
| Descriptor | Dehydrosqualene synthase, N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine (3 entities in total) |
| Functional Keywords | prenyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Staphylococcus aureus |
| Total number of polymer chains | 1 |
| Total formula weight | 34691.58 |
| Authors | Lin, F.-Y.,Li, K.,Liu, Y.-L.,Oldfield, E. (deposition date: 2012-03-21, release date: 2012-04-25, Last modification date: 2024-02-28) |
| Primary citation | Lin, F.Y.,Liu, Y.L.,Li, K.,Cao, R.,Zhu, W.,Axelson, J.,Pang, R.,Oldfield, E. Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets. J.Med.Chem., 55:4367-4372, 2012 Cited by PubMed: 22486710DOI: 10.1021/jm300208p PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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