3WCA

The complex structure of TcSQS with ligand, FSPP

Summary for 3WCA

Entry DOI	10.2210/pdb3wca/pdb
Related	3VJA 3WC9 3WCB 3WCC 3WCD 3WCE 3WCF 3WCG 3WCH 3WCI 3WCJ 3WCL 3WCM
Descriptor	Farnesyltransferase, putative, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	isoprenoids, drug discovery, trypanosoma cruzi squalene synthase, fspp, transferase
Biological source	Trypanosoma cruzi
Total number of polymer chains	4
Total formula weight	169512.11
Authors	Shang, N.,Li, Q.,Ko, T.P.,Chan, H.C.,Huang, C.H.,Oldfield, E.,Guo, R.T. (deposition date: 2013-05-26, release date: 2014-06-18, Last modification date: 2023-11-08)
Primary citation	Shang, N.,Li, Q.,Ko, T.P.,Chan, H.C.,Li, J.,Zheng, Y.,Huang, C.H.,Ren, F.,Chen, C.C.,Zhu, Z.,Galizzi, M.,Li, Z.H.,Rodrigues-Poveda, C.A.,Gonzalez-Pacanowska, D.,Veiga-Santos, P.,de Carvalho, T.M.,de Souza, W.,Urbina, J.A.,Wang, A.H.,Docampo, R.,Li, K.,Liu, Y.L.,Oldfield, E.,Guo, R.T. Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10:e1004114-e1004114, 2014 Cited by PubMed: 24789335 DOI: 10.1371/journal.ppat.1004114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation