3WCA

The complex structure of TcSQS with ligand, FSPP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Farnesyltransferase, putative	polymer	365	41861.8	4	UniProt (Q4CWB4) Pfam (PF00494) In PDB	Trypanosoma cruzi
2	A, B, C, D	S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE	non-polymer		398.4	5	Chemie (FPS)
3	A, B	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4		water	water		18.0	741	Chemie (HOH)

Sequence modifications

A, B, C, D: 25 - 368 (UniProt: Q4CWB4)

PDB	External Database	Details
Met 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag
Ser 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
Ser 14	-	expression tag
Ser 15	-	expression tag
Gly 16	-	expression tag
Leu 17	-	expression tag
Val 18	-	expression tag
Pro 19	-	expression tag
Arg 20	-	expression tag
Gly 21	-	expression tag
Ser 22	-	expression tag
His 23	-	expression tag
Met 24	-	expression tag
Glu 82	Asp 82	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	167447.2
Non-Polymers*	Number of molecules	8
	Total formula weight	2064.9
All*	Total formula weight	169512.1

*Water molecules are not included.