3WCA
The complex structure of TcSQS with ligand, FSPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045338 | biological_process | farnesyl diphosphate metabolic process |
| A | 0051996 | molecular_function | squalene synthase [NAD(P)H] activity |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045338 | biological_process | farnesyl diphosphate metabolic process |
| B | 0051996 | molecular_function | squalene synthase [NAD(P)H] activity |
| C | 0008610 | biological_process | lipid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0045338 | biological_process | farnesyl diphosphate metabolic process |
| C | 0051996 | molecular_function | squalene synthase [NAD(P)H] activity |
| D | 0008610 | biological_process | lipid biosynthetic process |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| D | 0045338 | biological_process | farnesyl diphosphate metabolic process |
| D | 0051996 | molecular_function | squalene synthase [NAD(P)H] activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE FPS A 501 |
| Chain | Residue |
| A | SER42 |
| A | GLN204 |
| A | ASN207 |
| A | HOH786 |
| A | HOH802 |
| A | HOH831 |
| A | SER44 |
| A | PHE45 |
| A | TYR64 |
| A | VAL171 |
| A | GLY172 |
| A | LEU175 |
| A | ALA196 |
| A | MET199 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | ASP71 |
| A | GLU74 |
| A | ASP75 |
| A | TYR163 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FPS B 401 |
| Chain | Residue |
| B | SER42 |
| B | SER44 |
| B | PHE45 |
| B | TYR64 |
| B | ARG68 |
| B | VAL171 |
| B | GLY172 |
| B | LEU175 |
| B | TYR179 |
| B | MET199 |
| B | GLY200 |
| B | LEU203 |
| B | GLN204 |
| B | ASN207 |
| B | TYR270 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 402 |
| Chain | Residue |
| B | ASP71 |
| B | GLU74 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG B 403 |
| Chain | Residue |
| B | ASP71 |
| B | HOH693 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FPS C 401 |
| Chain | Residue |
| C | SER42 |
| C | SER44 |
| C | PHE45 |
| C | TYR64 |
| C | ARG68 |
| C | GLY172 |
| C | LEU175 |
| C | ALA196 |
| C | MET199 |
| C | GLY200 |
| C | LEU203 |
| C | GLN204 |
| C | ASN207 |
| C | FPS402 |
| C | HOH694 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE FPS C 402 |
| Chain | Residue |
| C | PHE45 |
| C | TYR64 |
| C | ARG68 |
| C | ASP71 |
| C | VAL171 |
| C | GLN204 |
| C | ASN207 |
| C | ASP211 |
| C | ASP215 |
| C | FPS401 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE FPS D 401 |
| Chain | Residue |
| D | SER42 |
| D | SER44 |
| D | PHE45 |
| D | TYR64 |
| D | VAL171 |
| D | GLY172 |
| D | LEU175 |
| D | TYR179 |
| D | MET199 |
| D | GLY200 |
| D | LEU203 |
| D | ASN207 |
Functional Information from PROSITE/UniProt
| site_id | PS01044 |
| Number of Residues | 16 |
| Details | SQUALEN_PHYTOEN_SYN_1 Squalene and phytoene synthases signature 1. YChyVAGLVGhgLtlL |
| Chain | Residue | Details |
| A | TYR163-LEU178 |
| site_id | PS01045 |
| Number of Residues | 28 |
| Details | SQUALEN_PHYTOEN_SYN_2 Squalene and phytoene synthases signature 2. MGlflQkt.NIiRDFyeDicevpp.RvFwP |
| Chain | Residue | Details |
| A | MET199-PRO226 |
