4F6V

Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1034, mg2+ and fmp.

Summary for 4F6V

Entry DOI	10.2210/pdb4f6v/pdb
Descriptor	Dehydrosqualene synthase, 2,4-dioxo-4-{[3-(3-phenoxyphenyl)propyl]amino}butanoic acid, S,R MESO-TARTARIC ACID, ... (6 entities in total)
Functional Keywords	transferase, dehydrosqualene synthase, bph-1034, diketo acid, virulence factor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	35558.82
Authors	Lin, F.-Y.,Zhang, Y.,Liu, Y.-L.,Oldfield, E. (deposition date: 2012-05-15, release date: 2012-06-13, Last modification date: 2024-02-28)
Primary citation	Zhang, Y.,Lin, F.-Y.,Li, K.,Zhu, W.,Liu, Y.L.,Cao, R.,Pang, R.,Lee, E.,Axelson, J.,Hensler, M.,Wang, K.,Molohon, K.J.,Wang, Y.,Mitchell, D.A.,Nizet, V.,Oldfield, E. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3:402-406, 2012 Cited by PubMed: 22662288 DOI: 10.1021/ml300038t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation