4F6V

Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1034, mg2+ and fmp.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004311	molecular_function	farnesyltranstransferase activity
A	0009058	biological_process	biosynthetic process
A	0016117	biological_process	carotenoid biosynthetic process
A	0016120	biological_process	carotene biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0016767	molecular_function	geranylgeranyl-diphosphate geranylgeranyltransferase activity
A	0046872	molecular_function	metal ion binding
A	0046905	molecular_function	15-cis-phytoene synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ZYM A 301

Chain	Residue
A	PHE22
A	ARG171
A	ASP172
A	FJP303
A	MG304
A	MG305
A	HOH496
A	TYR41
A	CYS44
A	ARG45
A	ASP48
A	VAL133
A	VAL137
A	GLN165
A	ASN168

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SRT A 302

Chain	Residue
A	HIS18
A	SER19
A	LYS20
A	SER21
A	ARG171
A	ARG265
A	FJP303
A	MG304
A	HOH410
A	HOH490

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE FJP A 303

Chain	Residue
A	SER19
A	PHE22
A	PHE26
A	TYR41
A	ARG45
A	ALA134
A	GLY138
A	LEU160
A	GLY161
A	LEU164
A	ASN168
A	TYR248
A	ZYM301
A	SRT302
A	MG304

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 304

Chain	Residue
A	ASN168
A	ARG171
A	TYR248
A	ZYM301
A	SRT302
A	FJP303

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 305

Chain	Residue
A	ASN168
A	ASP172
A	ZYM301
A	HOH495
A	HOH496

---

Functional Information from PROSITE/UniProt

site_id	PS01044
Number of Residues	16
Details	SQUALEN_PHYTOEN_SYN_1 Squalene and phytoene synthases signature 1. YCygVAGTVGevLtpI

Chain	Residue	Details
A	TYR129-ILE144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:18276850, ECO:0007744|PDB:2ZCS, ECO:0007744|PDB:3W7F

Chain	Residue	Details
A	HIS18
A	TYR41

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:18276850, ECO:0007744|PDB:2ZCQ, ECO:0007744|PDB:3W7F

Chain	Residue	Details
A	ARG45

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:18276850, ECO:0007744|PDB:2ZCQ, ECO:0007744|PDB:3W7F

Chain	Residue	Details
A	ASP48
A	ASP52

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:18276850, ECO:0007744|PDB:2ZCQ, ECO:0007744|PDB:2ZCR

Chain	Residue	Details
A	GLN165

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:18276850, ECO:0007744|PDB:2ZCQ, ECO:0007744|PDB:2ZCR, ECO:0007744|PDB:3W7F

Chain	Residue	Details
A	ASN168
A	ASP172

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:18276850, ECO:0007744|PDB:3W7F

Chain	Residue	Details
A	ARG171
A	TYR248

---