3W7F
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from staphylococcus aureus complexed with farnesyl thiopyrophosphate
Replaces: 2ZCPSummary for 3W7F
| Entry DOI | 10.2210/pdb3w7f/pdb |
| Related | 2ZCO |
| Descriptor | Dehydrosqualene synthase, S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | crtm, fspp, carotenoid biosynthesis, staphyloxanthin biosynthesis, transferase, head-to-head condensation |
| Biological source | Staphylococcus aureus |
| Total number of polymer chains | 2 |
| Total formula weight | 71314.39 |
| Authors | Liu, C.I.,Jeng, W.Y.,Wang, A.H.,Oldfield, E. (deposition date: 2013-02-28, release date: 2013-04-10, Last modification date: 2023-11-08) |
| Primary citation | Liu, C.I.,Liu, G.Y.,Song, Y.,Yin, F.,Hensler, M.E.,Jeng, W.Y.,Nizet, V.,Wang, A.H.,Oldfield, E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science, 319:1391-1394, 2008 Cited by PubMed: 18276850DOI: 10.1126/science.1153018 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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