4E9U

Crystal structure of dehydrosqualene synthase (Crtm) from S. aureus complexed with a thiocyanate inhibitor

Summary for 4E9U

Entry DOI	10.2210/pdb4e9u/pdb
Related	4E9Z 4EA0 4EA1 4EA2
Descriptor	Dehydrosqualene synthase, 2-(4-phenoxyphenoxy)ethyl thiocyanate, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	prenyl transferase, thiocyanate inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	34656.67
Authors	Lin, F.-Y.,Axelson, J.,Liu, Y.-L.,Zhnag, Y.,Oldfield, E. (deposition date: 2012-03-21, release date: 2012-04-25, Last modification date: 2024-02-28)
Primary citation	Lin, F.Y.,Liu, Y.L.,Li, K.,Cao, R.,Zhu, W.,Axelson, J.,Pang, R.,Oldfield, E. Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets. J.Med.Chem., 55:4367-4372, 2012 Cited by PubMed: 22486710 DOI: 10.1021/jm300208p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation