4EA0
Crystal structure of dehydrosqualene synthase (Crtm) from S. aureus complexed with diphosphate and quinuclidine BPH-651
Summary for 4EA0
Entry DOI | 10.2210/pdb4ea0/pdb |
Related | 4E9U 4E9Z 4EA1 4EA2 |
Descriptor | Dehydrosqualene synthase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... (6 entities in total) |
Functional Keywords | quinuclidine inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 2 |
Total formula weight | 69928.64 |
Authors | Lin, F.-Y.,Liu, Y.-L.,Oldfield, E. (deposition date: 2012-03-21, release date: 2012-04-25, Last modification date: 2024-02-28) |
Primary citation | Lin, F.Y.,Liu, Y.L.,Li, K.,Cao, R.,Zhu, W.,Axelson, J.,Pang, R.,Oldfield, E. Head-to-Head Prenyl Tranferases: Anti-Infective Drug Targets. J.Med.Chem., 55:4367-4372, 2012 Cited by PubMed: 22486710DOI: 10.1021/jm300208p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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