4H2J

Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1354

Summary for 4H2J

• Entry DOI: 10.2210/pdb4h2j/pdb
• Related: 4H2M 4H2O 4H38 4H3A 4H3C
• Descriptor: Undecaprenyl pyrophosphate synthase, N~4~-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N~1~-[4-(1H-imidazol-2-yl)phenyl]-2-nitrobenzene-1,4-dicarboxamide (3 entities in total)
• Functional Keywords: prenyl transferase inhibitor complex, alpha-helix, prenyl transferase, cell wall biosynthesis, farnesyl diphosphate binding, isopentenyl diphosphate binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57953.23

Authors

Zhu, W.,Oldfield, E. (deposition date: 2012-09-12, release date: 2012-12-19, Last modification date: 2023-09-20)

• Primary citation: Zhu, W.,Zhang, Y.,Sinko, W.,Hensler, M.E.,Olson, J.,Molohon, K.J.,Lindert, S.,Cao, R.,Li, K.,Wang, K.,Wang, Y.,Liu, Y.L.,Sankovsky, A.,de Oliveira, C.A.,Mitchell, D.A.,Nizet, V.,McCammon, J.A.,Oldfield, E.; Antibacterial drug leads targeting isoprenoid biosynthesis.; Proc.Natl.Acad.Sci.USA, 110:123-128, 2013; PubMed: 23248302; DOI: 10.1073/pnas.1219899110

Experimental method

X-RAY DIFFRACTION (1.81 Å)