7M94
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![BU of 7m94 by Molmil](/molmil-images/mine/7m94) | Bovine sigma-2 receptor bound to Roluperidone | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Roluperidone, Sigma intracellular receptor 2 | 著者 | Alon, A, Kruse, A.C. | 登録日 | 2021-03-30 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600, 2021
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7M96
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![BU of 7m96 by Molmil](/molmil-images/mine/7m96) | Bovine sigma-2 receptor bound to Z4857158944 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-({[(1S)-1-hydroxy-2-methyl-1-phenylpropan-2-yl]amino}methyl)-1-methyl-3,4-dihydroquinolin-2(1H)-one, ... | 著者 | Alon, A, Kruse, A.C. | 登録日 | 2021-03-30 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600, 2021
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7M93
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![BU of 7m93 by Molmil](/molmil-images/mine/7m93) | Bovine sigma-2 receptor bound to PB28 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, PB28, Sigma intracellular receptor 2 | 著者 | Alon, A, Kruse, A.C. | 登録日 | 2021-03-30 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Structures of the sigma 2 receptor enable docking for bioactive ligand discovery. Nature, 600, 2021
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3HK1
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![BU of 3hk1 by Molmil](/molmil-images/mine/3hk1) | Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins | 分子名称: | 4-{[2-(methoxycarbonyl)-5-(2-thienyl)-3-thienyl]amino}-4-oxo-2-butenoic acid, Fatty acid-binding protein, adipocyte | 著者 | Hertzel, A.V, Hellberg, K, Reynolds, J.M, Kruse, A.C, Juhlmann, B.E, Smith, A.J, Sanders, M.A, Ohlendorf, D.H, Suttles, J, Bernlohr, D.A. | 登録日 | 2009-05-22 | 公開日 | 2009-09-22 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. J.Med.Chem., 52, 2009
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3I46
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![BU of 3i46 by Molmil](/molmil-images/mine/3i46) | Crystal structure of beta toxin from Staphylococcus aureus F277A, P278A mutant with bound calcium ions | 分子名称: | Beta-hemolysin, CALCIUM ION, CHLORIDE ION | 著者 | Huseby, M, Shi, K, Kruse, A.C, Ohlendorf, D.H. | 登録日 | 2009-07-01 | 公開日 | 2010-07-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure and biological functions of beta toxin from Staphylococcus aureus: Role of the hydrophobic beta hairpin in virulence To be Published
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3I48
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![BU of 3i48 by Molmil](/molmil-images/mine/3i48) | Crystal structure of beta toxin from Staphylococcus aureus F277A, P278A mutant with bound magnesium ions | 分子名称: | Beta-hemolysin, MAGNESIUM ION, PHOSPHATE ION | 著者 | Huseby, M, Shi, K, Kruse, A.C, Ohlendorf, D.H. | 登録日 | 2009-07-01 | 公開日 | 2010-07-14 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure and biological functions of beta toxin from Staphylococcus aureus: Role of the hydrophobic beta hairpin in virulence to be published, 2009
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3I5V
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![BU of 3i5v by Molmil](/molmil-images/mine/3i5v) | |
3I41
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5HK2
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![BU of 5hk2 by Molmil](/molmil-images/mine/5hk2) | Human sigma-1 receptor bound to 4-IBP | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, N-(1-benzylpiperidin-4-yl)-4-iodobenzamide, SULFATE ION, ... | 著者 | Schmidt, H.R, Zheng, S, Gurpinar, E.G, Koehl, A, Manglik, A, Kruse, A.C. | 登録日 | 2016-01-13 | 公開日 | 2016-04-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of the human sigma 1 receptor. Nature, 532, 2016
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3SN6
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![BU of 3sn6 by Molmil](/molmil-images/mine/3sn6) | Crystal structure of the beta2 adrenergic receptor-Gs protein complex | 分子名称: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid antibody VHH fragment, Endolysin,Beta-2 adrenergic receptor, ... | 著者 | Rasmussen, S.G.F, DeVree, B.T, Zou, Y, Kruse, A.C, Chung, K.Y, Kobilka, T.S, Thian, F.S, Chae, P.S, Pardon, E, Calinski, D, Mathiesen, J.M, Shah, S.T.A, Lyons, J.A, Caffrey, M, Gellman, S.H, Steyaert, J, Skiniotis, G, Weis, W.I, Sunahara, R.K, Kobilka, B.K. | 登録日 | 2011-06-28 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of the beta2 adrenergic receptor-Gs protein complex Nature, 477, 2011
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5IUS
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![BU of 5ius by Molmil](/molmil-images/mine/5ius) | Crystal structure of human PD-L1 in complex with high affinity PD-1 mutant | 分子名称: | CHLORIDE ION, Programmed cell death 1 ligand 1, Programmed cell death protein 1 | 著者 | Pascolutti, R, Sun, X, Kao, J, Maute, R, Ring, A.M, Bowman, G.R, Kruse, A.C. | 登録日 | 2016-03-18 | 公開日 | 2016-09-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.889 Å) | 主引用文献 | Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant. Structure, 24, 2016
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5HK1
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![BU of 5hk1 by Molmil](/molmil-images/mine/5hk1) | Human sigma-1 receptor bound to PD144418 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-(4-methylphenyl)-5-(1-propyl-3,6-dihydro-2H-pyridin-5-yl)-1,2-oxazole, SULFATE ION, ... | 著者 | Schmidt, H.R, Zheng, S, Gurpinar, E, Koehl, A, Manglik, A, Kruse, A.C. | 登録日 | 2016-01-13 | 公開日 | 2016-04-06 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.5051 Å) | 主引用文献 | Crystal structure of the human sigma 1 receptor. Nature, 532, 2016
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3UON
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![BU of 3uon by Molmil](/molmil-images/mine/3uon) | Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist | 分子名称: | (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate, CHLORIDE ION, Human M2 muscarinic acetylcholine, ... | 著者 | Haga, K, Kruse, A.C, Asada, H, Yurugi-Kobayashi, T, Shiroishi, M, Zhang, C, Weis, W.I, Okada, T, Kobilka, B.K, Haga, T, Kobayashi, T. | 登録日 | 2011-11-16 | 公開日 | 2012-02-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature, 482, 2012
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5JQH
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![BU of 5jqh by Molmil](/molmil-images/mine/5jqh) | Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60 | 分子名称: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, CHOLESTEROL, Endolysin,Beta-2 adrenergic receptor, ... | 著者 | Staus, D.P, Strachan, R.T, Manglik, A, Pani, B, Kahsai, A.W, Kim, T.H, Wingler, L.M, Ahn, S, Chatterjee, A, Masoudi, A, Kruse, A.C, Pardon, E, Steyaert, J, Weis, W.I, Prosser, R.S, Kobilka, B.K, Costa, T, Lefkowitz, R.J. | 登録日 | 2016-05-05 | 公開日 | 2016-07-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature, 535, 2016
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6D35
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![BU of 6d35 by Molmil](/molmil-images/mine/6d35) | Crystal structure of Xenopus Smoothened in complex with cholesterol | 分子名称: | CHOLESTEROL, Smoothened,Soluble cytochrome b562,Smoothened | 著者 | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | 登録日 | 2018-04-14 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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6D32
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![BU of 6d32 by Molmil](/molmil-images/mine/6d32) | Crystal structure of Xenopus Smoothened in complex with cyclopamine | 分子名称: | Cyclopamine, Smoothened,Soluble cytochrome b562,Smoothened | 著者 | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | 登録日 | 2018-04-14 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.751 Å) | 主引用文献 | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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6DO1
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![BU of 6do1 by Molmil](/molmil-images/mine/6do1) | Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-like peptide S1I8, ... | 著者 | Wingler, L.M, McMahon, C, Staus, D.P, Lefkowitz, R.J, Kruse, A.C. | 登録日 | 2018-06-08 | 公開日 | 2019-01-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | 主引用文献 | Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell, 176, 2019
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6DK0
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![BU of 6dk0 by Molmil](/molmil-images/mine/6dk0) | Human sigma-1 receptor bound to NE-100 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GLYCEROL, N-{2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl}-N-propylpropan-1-amine, ... | 著者 | Schmidt, H.R, Kruse, A.C. | 登録日 | 2018-05-28 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis for sigma1receptor ligand recognition. Nat. Struct. Mol. Biol., 25, 2018
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6DJZ
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![BU of 6djz by Molmil](/molmil-images/mine/6djz) | Human sigma-1 receptor bound to haloperidol | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one, GLYCEROL, ... | 著者 | Schmidt, H.R, Kruse, A.C. | 登録日 | 2018-05-28 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.084 Å) | 主引用文献 | Structural basis for sigma1receptor ligand recognition. Nat. Struct. Mol. Biol., 25, 2018
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6DK1
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![BU of 6dk1 by Molmil](/molmil-images/mine/6dk1) | Human sigma-1 receptor bound to (+)-pentazocine | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,6S,11S)-6,11-dimethyl-3-(3-methylbut-2-en-1-yl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol, GLYCEROL, ... | 著者 | Schmidt, H.R, Kruse, A.C. | 登録日 | 2018-05-28 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Structural basis for sigma1receptor ligand recognition. Nat. Struct. Mol. Biol., 25, 2018
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8UWL
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![BU of 8uwl by Molmil](/molmil-images/mine/8uwl) | 5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | 分子名称: | 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G. | 登録日 | 2023-11-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | AlphaFold2 structures guide prospective ligand discovery. Science, 384, 2024
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8V6U
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![BU of 8v6u by Molmil](/molmil-images/mine/8v6u) | 5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking | 分子名称: | 4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol, 5-hydroxytryptamine receptor 2A, G protein alpha-subunit q (Gi2-mini-Gq chimera), ... | 著者 | Gumpper, R.H, Wang, L, Kapolka, N, Skiniotis, G, Roth, B.L. | 登録日 | 2023-12-03 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | AlphaFold2 structures guide prospective ligand discovery. Science, 384, 2024
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6BE6
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![BU of 6be6 by Molmil](/molmil-images/mine/6be6) | ADAM10 Extracellular Domain | 分子名称: | CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 10, SULFATE ION, ... | 著者 | Seegar, T.C.M. | 登録日 | 2017-10-24 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10. Cell, 171, 2017
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6BDZ
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3TJH
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![BU of 3tjh by Molmil](/molmil-images/mine/3tjh) | 42F3-p3A1/H2-Ld complex | 分子名称: | 42F3 alpha, 42F3 beta, H2-Ld SBM2, ... | 著者 | Adams, J.J, Kruse, A, Kranz, D.M, Garcia, K.C. | 登録日 | 2011-08-24 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity, 35, 2011
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