8UWL

5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)

Summary for 8UWL

• Entry DOI: 10.2210/pdb8uwl/pdb
• EMDB information: 42676
• Descriptor: 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: 5-ht2a receptor, serotonin receptor, g protein, gpcr, lisuride, cryoem, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 142527.87

Authors

Barros-Alvarez, X.,Kim, K.,Panova, O.,Roth, B.L.,Skiniotis, G. (deposition date: 2023-11-06, release date: 2024-05-29, Last modification date: 2024-07-03)

• Primary citation: Lyu, J.,Kapolka, N.,Gumpper, R.,Alon, A.,Wang, L.,Jain, M.K.,Barros-Alvarez, X.,Sakamoto, K.,Kim, Y.,DiBerto, J.,Kim, K.,Glenn, I.S.,Tummino, T.A.,Huang, S.,Irwin, J.J.,Tarkhanova, O.O.,Moroz, Y.,Skiniotis, G.,Kruse, A.C.,Shoichet, B.K.,Roth, B.L.; AlphaFold2 structures guide prospective ligand discovery.; Science, 384:eadn6354-eadn6354, 2024; PubMed: 38753765; DOI: 10.1126/science.adn6354

Experimental method

ELECTRON MICROSCOPY (2.8 Å)