5IUS

Crystal structure of human PD-L1 in complex with high affinity PD-1 mutant

Summary for 5IUS

• Entry DOI: 10.2210/pdb5ius/pdb
• Descriptor: Programmed cell death protein 1, Programmed cell death 1 ligand 1, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: immune checkpoint, tumor surveillance, cancer, receptor, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: Q15116; Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7
• Total number of polymer chains: 4
• Total formula weight: 79927.22

Authors

Pascolutti, R.,Sun, X.,Kao, J.,Maute, R.,Ring, A.M.,Bowman, G.R.,Kruse, A.C. (deposition date: 2016-03-18, release date: 2016-09-28, Last modification date: 2023-09-27)

• Primary citation: Pascolutti, R.,Sun, X.,Kao, J.,Maute, R.L.,Ring, A.M.,Bowman, G.R.,Kruse, A.C.; Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant.; Structure, 24:1719-1728, 2016; PubMed: 27618663; DOI: 10.1016/j.str.2016.06.026

Experimental method

X-RAY DIFFRACTION (2.889 Å)