6DO1

Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8

Summary for 6DO1

Entry DOI	10.2210/pdb6do1/pdb
Descriptor	Type-1 angiotensin II receptor,Soluble cytochrome b562 BRIL fusion protein, Nanobody Nb.AT110i1, Angiotensin-like peptide S1I8, ... (7 entities in total)
Functional Keywords	nanobody, gpcr, synthetic antibody, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	156220.47
Authors	Wingler, L.M.,McMahon, C.,Staus, D.P.,Lefkowitz, R.J.,Kruse, A.C. (deposition date: 2018-06-08, release date: 2019-01-30, Last modification date: 2023-10-11)
Primary citation	Wingler, L.M.,McMahon, C.,Staus, D.P.,Lefkowitz, R.J.,Kruse, A.C. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell, 176:479-490.e12, 2019 Cited by PubMed: 30639100 DOI: 10.1016/j.cell.2018.12.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.901 Å)

Structure validation